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Permanent link (DOI): https://doi.org/10.7939/R3513V64V

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The Oxa2 protein of Neurospora crassa plays a critical role in the biogenesis of cytochrome oxidase and defines a ubiquitous subbranch of the Oxa1/YidC/Alb3 protein family Open Access

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Author or creator
Funes, S.
Nargang, F.E.
Neupert, W.
Herrmann, J.M.
Additional contributors
Subject/Keyword
functional complementation
nuclear gene
alternative oxidase
export machinery
N-termini
C-termini
inner membrane
saccharomyces-cerevisiae
homolog albino3
mitochondria
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Proteins of the Oxa1/YidC/Alb3 family mediate the insertion of proteins into membranes of mitochondria, bacteria, and chloroplasts. Here we report the identification of a second gene of the Oxa1/YidC/Alb3 family in the genome of Neurospora crassa, which we have named oxa2. Its gene product, Oxa2, is located in the inner membrane of mitochondria. Deletion of the oxa2 gene caused a specific defect in the biogenesis of cytochrome oxidase and resulted in induction of the alternative oxidase (AOD), which bypasses the need for complex IV of the respiratory chain. The Oxa2 protein of N. crassa complements Cox18-deficient yeast mutants suggesting a common function for both proteins. The oxa2 sequence allowed the identification of a new subfamily of Oxa1/YidC/Alb3 proteins whose members appear to be ubiquitously present in mitochondria of fungi, plants, and animals including humans.
Date created
2004
DOI
doi:10.7939/R3513V64V
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Copyright 2004 by The American Society for Cell Biology
Citation for previous publication
Funes, S., Nargang, F.E., Neupert, W., and Herrmann, J.M. (2004). The Oxa2 protein of Neurospora crassa plays a critical role in the biogenesis of cytochrome oxidase and defines a ubiquitous subbranch of the Oxa1/YidC/Alb3 protein family. Molecular Biology of the Cell, 15 (April), 1853–1861. DOI: 10.1091/mbc.E03-11-0789
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