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Alteration of liver fat metabolism following irinotecan plus 5-fluorouracil treatment Open Access


Other title
liver fat metabolism
colorectal cancer
Type of item
Degree grantor
University of Alberta
Author or creator
Pant, Asha
Supervisor and department
Dr Vera Mazurak, Agricultural, Food and Nutritional Science
Examining committee member and department
Dr Jason Yap, Department of Medicine
Dr Rene Jacobs, Agricultural, food and Nutritional Science
Dr Vickie Baracos, Oncology and Agricultural, food and Nutrition Science
Department of Agricultural, Food and Nutritional Science

Date accepted
Graduation date
Master of Science
Degree level
This study determined how chemotherapy treatment for colorectal cancer alters hepatic fat metabolism. Livers were isolated from tumor-bearing animals after one and two cycles of chemotherapy consisting of irinotecan plus 5-fluorouracil. Fatty acid amounts and composition within triglycerides (TG) and phospholipids (PL) as well as gene expression were assessed. Total TG did not change and total PL were higher after 7 days following treatment. Docosahexaenoic acid became undetectable after the treatment at 5 and 7 days, respectively. Following one cycle, the alterations appeared temporary. After second cycle, total TG were lower and n-3 fatty acids were also lower causing n-6/n-3 ratio to be higher. Chemotherapy altered 13 genes of 44, however not all genes within a single pathway were affected. The alterations in gene expression did not necessarily parallel the observations in fatty acids. This study is important to develop identify target pathways to circumvent negative effects of chemotherapy-associated steatohepatitis.
License granted by Asha Pant ( on 2011-09-30T15:13:20Z (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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