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Permanent link (DOI): https://doi.org/10.7939/R3XS6F

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Theses and Dissertations

Urine metabolomics and colorectal cancer screening Open Access

Descriptions

Other title
Subject/Keyword
public health
screening
polyps
urine metabolomics
colorectal cancer
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Wang, Haili
Supervisor and department
Fedorak, Richard (Gastroenterology)
Examining committee member and department
Fedorak, Richard (Gastroenterology)
Schiller, Dan (Surgery)
Goodman, Karen (Gastroenterolgy & School of Public Health)
Adamko, Darryl (Pediatirc Pulmonary Medicine)
Befus, Dean (Pulmonary Medicine)
Clarence (Gastroenterology)
Department
School Public Health Sciences
Specialization

Date accepted
2012-05-31T10:26:03Z
Graduation date
2011-06
Degree
Master of Science
Degree level
Master's
Abstract
Colorectal cancer (CRC) is a major public health concern. The current population-based screening method used world-wide is fecal occult blood testing (FOBT), however this test has very low sensitivity for both colorectal cancer and adenomatous (pre-cancerous) polyps and is associated with low compliance. Metabolomics is a new field of science to study small molecules of metabolism and existing literature on metabolomics and CRC is limited. In this thesis, urine metabolomics has been shown to represent a novel, non-invasive, well-accepted screening tool for detecting CRC and adenomatous polyps with high sensitivity. The metabolomic fingerprint of CRC and that of adenomatous polyps have been explored to further understand metabolic changes in these disease states. After curative treatment of CRC, the CRC metabolomic fingerprint has been shown to remain.
Language
English
DOI
doi:10.7939/R3XS6F
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File title: Haili's Thesis - final.pdf
File title: Haili's Thesis - final
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