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Evaluating Therapies and Outcomes in Acute and Chronic Heart Failure Open Access


Other title
Cardiac resynchronization therapy
Cardiac biomarkers
Heart failure
Type of item
Degree grantor
University of Alberta
Author or creator
Almajed, Nawaf S
Supervisor and department
McAlister, Finlay (Medicine)
Ezekowitz, Justin (Medicine)
Armstrong, Paul (Medicine)
Examining committee member and department
Ezekowitz, Justin (Medicine)
McAlister, Finlay (Medicine)
Armstrong, Paul (Medicine)
Tsuyuki, Ross (Medicine)
Department of Medicine
Experimental Medicine
Date accepted
Graduation date
Master of Science
Degree level
Heart failure is common, and is associated with significant mortality, morbidity, and reduced quality of life. The objective of this thesis is to evaluate some therapeutic interventions and outcomes in patients with acute and chronic heart failure. In the first part, the efficacy of cardiac resynchronization therapy in patients with heart failure was explored, with more focus on patients with mild symptoms. Although cardiac resynchronization was found to reduce mortality and heart failure hospitalization and improve left ventricular ejection fraction in patients with mild symptoms, it did not improve functional outcomes, like quality of life or 6-minute walk test. In the second part of this thesis, the role of peak expiratory flow rate in assessing dyspnea improvement in patients with acute heart failure was evaluated by testing its correlation with NT-proBNP, a known prognostic marker. No significant correlation was found between short term changes in peak expiratory flow and NT-proBNP.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
[Al-majed et al. Ann Intern Med. 2011 Mar 15;154(6):401-12]

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