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Permanent link (DOI): https://doi.org/10.7939/R31G00

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Is Belief Larger than Fact: Expectations, Optimism and Reality for Translational Stem Cell Research Open Access

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Author or creator
Bubela, Tania
D Li, Matthew
Hafez, Mohamed
Bieber, Mark
Atkins, Harold
Additional contributors
Subject/Keyword
commercialization
public expectations
newspaper coverage
stem cell therapy
clinical trials
ethics
Type of item
Research Material
Language
English
Place
Time
Description
Background Stem cell (SC) therapies hold remarkable promise for many diseases, but there is a significant gulf between public expectations and the reality of progress toward clinical application. Public expectations are fueled by stakeholder arguments for research and public funding, coupled with intense media coverage in an ethically charged arena. We examine media representations in light of the expanding global landscape of SC clinical trials, asking what patients may realistically expect by way of timelines for the therapeutic and curative potential of regenerative medicine? Methods We built 2 international datasets: (1) 3,404 clinical trials (CT) containing 'stem cell*' from ClinicalTrials.gov and the World Health Organization's International Clinical Trials Registry Search Portal; and (2) 13,249 newspaper articles on SC therapies using Factiva.com. We compared word frequencies between the CT descriptions and full-text newspaper articles for the number containing terms for SC type and diseases/conditions. We also developed inclusion and exclusion criteria to identify novel SC CTs, mainly regenerative medicine applications. Results Newspaper articles focused on human embryonic SCs and neurological conditions with significant coverage as well of cardiovascular disease and diabetes. In contrast, CTs used primarily hematopoietic SCs, with an increase in CTs using mesenchymal SCs since 2007. The latter dominated our novel classification for CTs, most of which are in phases I and II. From the perspective of the public, expecting therapies for neurological conditions, there is limited activity in what may be considered novel applications of SC therapies. Conclusions Given the research, regulatory, and commercialization hurdles to the clinical translation of SC research, it seems likely that patients and political supporters will become disappointed and disillusioned. In this environment, proponents need to make a concerted effort to temper claims. Even though the field is highly promising, it lacks significant private investment and is largely reliant on public support, requiring a more honest acknowledgement of the expected therapeutic benefits and the timelines to achieving them.
Date created
2014/10/24
DOI
doi:10.7939/R31G00
License information
Creative Commons Attribution-Non-Commercial-No Derivatives 3.0 Unported
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Citation for previous publication
Bubela T, Li MD, Hafez M, Bieber M, Atkins H (2012) Is Belief Larger than Fact: Expectations, Optimism and Reality for Translational Stem Cell Research. BMC Medicine DOI: 10.1186/1741-7015-10-133.
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2014-10-24T19:55:16.486+00:00
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File format: pdf (Portable Document Format)
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File size: 1239466
Last modified: 2015:10:12 11:41:17-06:00
Filename: BMC 10(133) 2012.pdf
Original checksum: 163e4a6e277945ffa0e981f5032cb9bd
Copyright note: ?? 2012 Bubela et al; licensee BioMed Central Ltd.
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File title: Abstract
File title: Is belief larger than fact: expectations, optimism and reality for translational stem cell research
File author: Tania Bubela
Page count: 10
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