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Permanent link (DOI): https://doi.org/10.7939/R35H1Z

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Alterations in adipose tissue in colorectal cancer patients Open Access

Descriptions

Other title
Subject/Keyword
Colorectal cancer
Adipose tissue
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Ebadi, Maryam
Supervisor and department
Mazurak, Vera (Agricultural, Food and Nutritional Science)
Examining committee member and department
Frenette,Jérôme (Rehabilitation)
Baracos, Vickie (Oncology)
Field, Catherine ( Agricultural, Food and Nutritional Science)
Department
Department of Agricultural, Food, and Nutritional Science
Specialization
Nutrition and Metabolism
Date accepted
2012-07-18T09:42:36Z
Graduation date
2012-11
Degree
Master of Science
Degree level
Master's
Abstract
Mechanisms underlying fat loss in cancer are not well understood. Knowing the types of fat being lost from adipose tissue may help define interventions to circumvent wasting. The aim of this study was to explore the differences in adipokines and fatty acid composition between visceral adipose tissue (VAT) and subcutaneous (SAT) depots and relate this to fat mass changes (expressed as %change /100d) assessed using computed tomography images. Adipose tissue samples were obtained intraoperatively from advanced colorectal cancer patients (n=16). The findings indicate that fat was more commonly lost than gained. VAT was not preserved in cancer patients throughout the disease progression. Greater amounts of n-6 fatty acids in VAT were associated with greater fat loss in cancer patients. There were higher levels of leptin in SAT than VAT and higher monocyte chemotactic protein-1 (MCP-1) amounts in VAT. Future work will investigate the mechanisms of fat loss in cancer patients.
Language
English
DOI
doi:10.7939/R35H1Z
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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