Download the full-sized PDF
This file is in the following communities:
|Department of Surgery|
This file is not currently in any collections.
The probiotic bacterium Lactobacillus plantarum species 299 reduces intestinal permeability in experimental biliary obstruction Open Access
- Author or creator
- Additional contributors
intestinal barrier function
- Type of item
- Journal Article (Published)
Aims: Extrahepatic biliary obstruction is associated with the failure of intestinal barrier function, allowing bacteria and other substances from the intestine to enter the circulation and initiate a systemic inflammatory response, causing impairment of organ function. Probiotic bacteria have been shown to have beneficial effects on intestinal barrier function in other conditions, but their effects have never been studied in biliary obstruction. Methods and Results: This study examined the effects of enteral administration of Lactobacillus plantarum species 299 (LP299) in oatmeal fibre compared with sterile oatmeal fibre in water or water alone in an animal model of biliary obstruction. Administration of LP299 was associated with reduced intestinal permeability compared with sterile oatmeal alone (0Æ262 ± 0Æ105% vs 0Æ537 ± 0Æ037%, P = 0Æ019, percentage excretion of 14Carbon), but there was no evidence of reduced endotoxin exposure or blunting of the systemic inflammatory response. Animals receiving sterile oatmeal fibre alone also failed to develop the hyperpermeability after biliary obstruction seen in animals receiving water only (0Æ512 ± 0Æ05% vs 0Æ788 ± 0Æ18%), suggesting that oatmeal itself may have some beneficial effects on intestinal barrier function. Conclusion: Enteral administration of the probiotic bacterium LP299 reduces intestinal hyperpermeability associated with experimental biliary obstruction. Significance and Impact of the Study: This study provides insight to direct further work into the modulation of intestinal barrier function by probiotic bacteria.
- Date created
- License information
- This item is open access. The source...
- Citation for previous publication
White, J. S., Hoper, M., Parks, R. W., Clements, W. D. B., Diamond, T., & Bengmark, S. (2006). The probiotic bacterium Lactobacillus plantarum species 299 reduces intestinal permeability in experimental biliary obstruction. Letters in Applied Microbiology, 42(1): 19-23. doi:10.1111/j.1472-765X.2005.01800.x
- Link to related item
- Date Uploaded
- Date Modified
- Audit Status
- Audits have not yet been run on this file.
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 108368
Last modified: 2015:10:12 17:24:11-06:00
Filename: The probiotic bacterium.pdf
Original checksum: 3b94be734ee8e494bb613decff9c71fc
Well formed: true
File title: The probiotic bacterium Lactobacillus plantarum species 299 reduces intestinal permeability in experimental biliary obstruction
Page count: 5