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Permanent link (DOI): https://doi.org/10.7939/R30619

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Glutamate in the medial prefrontal cortex in the early postpartum Open Access

Descriptions

Other title
Subject/Keyword
Neuroactive Steroids
Neuroimaging
Glutamate
Magnetic Resonance Spectroscopy
Postpartum Depression
Prefrontal Cortex
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Mitchell, Nicholas D
Supervisor and department
LeMelledo, Jean-Michel (Psychiatry)
Examining committee member and department
Baker, Glen (Psychiatry)
Hanstock, Christopher (Biomedical Engineering)
Department
Department of Psychiatry
Specialization

Date accepted
2011-10-03T21:13:32Z
Graduation date
2011-11
Degree
Master of Science
Degree level
Master's
Abstract
Risk factors for postpartum depression (PPD) include history of a major depressive episode, premenstrual dysphoric disorder, or a prior episode of PPD. Fluctuations in estrogen, progesterone, and neuroactive steroids occur in the postpartum, and these molecules act as modulators of a number of neurotransmitter systems, including that of glutamate (Glu). Recent investigations demonstrate alterations in brain Glu levels in mood disorders, and fluctuations in brain Glu have been demonstrated in response to hormone changes over the menstrual cycle. Using magnetic resonance spectroscopy to measure Glu in the medial prefrontal cortex (MPFC) in the early postpartum, the studies presented in this thesis demonstrate decreases in MPFC Glu levels compared to the follicular phase of the menstrual cycle (FP), and in women with risk factors for PPD compared to women without risk factors. Alterations in MPFC Glu occurring in the early postpartum may be related to the development of PPD.
Language
English
DOI
doi:10.7939/R30619
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File title: Glutamate in the Medial Prefrontal Cortex in the Early Postpartum
File author: Nick Mitchell
Page count: 103
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