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Development of Flexible-Based Electrode Array for Spinal Cord Interface Open Access


Other title
Spinal cord
Multi-electrode array
Type of item
Degree grantor
University of Alberta
Author or creator
Khaled, Imad M.
Supervisor and department
Vivian Mushahwar (Cell Biology)
Walied Moussa (Mechanical Engineering)
Examining committee member and department
Kajsa Duke (Mechanical Engineering)
Samer Adeeb (Civil and Environmental Engineering)
Department of Mechanical Engineering

Date accepted
Graduation date
Master of Science
Degree level
Multi-electrode arrays are essential tools to interface with the nervous system. The development of a flexible-based electrode array used to interface with the spinal cord is reported. A 2D finite element model (FEM) was developed to characterize the design parameters of such an array. A customizable, feasible and repeatable fabrication process is presented. The mechanical properties of the developed prototypes were characterized using the dynamic mechanical analysis. The arrays were implanted into surrogate cords that mimic the human spinal cord. The comparison between the strains measured across the cords implanted with flexible-based arrays and the ones implanted with other types of arrays (solid-based and individual wires) showed that the former arrays are mechanically more compliant with the cord than the rigid-based arrays. The experimental results validated the FEM, which was used to analyze the stresses induced by the electrodes of the different types of arrays on the cord. The obtained results confirmed the mechanical compliance of the flexible-based arrays with the cords.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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