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Theses and Dissertations

The use of PET/CT scans in the assessment of resectability of colorectal liver metastases Open Access


Other title
liver metastases
colorectal cancer
surgial resectability
Type of item
Degree grantor
University of Alberta
Author or creator
Patel, Seema
Supervisor and department
Bigam, David (Surgery)
Ohinmaa, Arto (Public Health Sciences)
Examining committee member and department
Jacobs, Philip (Public Health Sciences)
Saunders, Duncan (Public Health Sciences)
Department of Public Health Sciences

Date accepted
Graduation date
Master of Science
Degree level
Background: Surgical treatment of colorectal liver metastases (CLRM) depends on resectability that is currently based on the CT scan. With the PET/CT scan, a more accurate pre-operative assessment of resectability may be possible. Methods: A Cochrane-based diagnostic test systematic review and a systematic review of cost-effectiveness studies on PET scans were conducted. Lastly, a diagnostic decision analysis model was created to assess the cost-effectiveness of the technology. Results: PET/CT scans was equally sensitive for hepatic metastases and more sensitive for extra-hepatic metastases compared to CT scans. A cost-savings of PET scans for CRLM is identified; with decision modelling demonstrating a cost-savings with the addition of PET/CT scans to the current clinical algorithm. Conclusion: There is cautious support for the addition of PET/CT scans to the pre-operative assessment in CRLM. Unnecessary surgery may be prevented, thus decreasing wait times. Future endeavours include finding, evaluating and validating methodology for appropriate effectiveness measures.
License granted by Seema Patel ( on 2011-04-11T17:54:59Z (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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