Download the full-sized PDF
Permanent link (DOI): https://doi.org/10.7939/R3BV7B41N
This file is in the following communities:
|Graduate Studies and Research, Faculty of|
This file is in the following collections:
|Theses and Dissertations|
Fabrication of colloidal crystals featuring sub-20 nm pore size for protein separation Open Access
- Other title
- Type of item
- Degree grantor
University of Alberta
- Author or creator
- Supervisor and department
Harrison, D. Jed
Kostiuk, Larry W.
- Examining committee member and department
Olfert, Jason (Mechanical Engineering)
Kostiuk, Larry W. (Mechanical Engineering)
Harrison, D. Jed (Chemistry)
Department of Mechanical Engineering
- Date accepted
- Graduation date
Master of Science
- Degree level
Clinical point-of-care (POC) diagnosis remains an open and challenging field of
research worldwide in which the study of the mechanism and dynamics of protein
molecule separation using electrophoresis is of considerable interest.
The quality of a protein separation is strongly dependent on the separating matrix
and conditions under which the electrophoresis is performed. This research is
mainly focused on development of a novel separation matrix, based upon the selfassembly
of particles in a colloidal suspension, within a microfluidic chip.
Several challenges were overcome in developing crystalline particle arrays that
generate a porous material with pores smaller than 20 nm. The effect of pore size
on separation of proteins of differing molecular weight and size was then studied,
and the mechanism of separation, which appears to change in the smallest size
range, was explored.
- Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
- Citation for previous publication
- Date Uploaded
- Date Modified
- Audit Status
- Audits have not yet been run on this file.
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 4793300
Last modified: 2015:10:12 16:30:15-06:00
Filename: Malekpourkoupaei_Ali_Fall 2012.pdf
Original checksum: ec0e2b70832d70e38393db391a7f6020
Well formed: false
Status message: Invalid page tree node offset=371849
Status message: Unexpected error in findFonts java.lang.ClassCastException: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject cannot be cast to edu.harvard.hul.ois.jhove.module.pdf.PdfDictionary offset=4769479
Status message: Outlines contain recursive references.
File title: title_page
Page count: 58