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Poly n-butylcyanoacrylate (PNBCA) nanocapsules as a carrier for NSAIDs: in vitro release and in vivo skin penetration Open Access


Author or creator
Miyazaki, S.
Takahashi, A.
Kubo, W.
Bachynsky, J.
Löbenberg, R.
Additional contributors
Polybutylcyanoacrylate nanoparticles
Pharmaceutical application
Loaded nanoparticles
Pluronic F-127 gels
Tissue distribution
Biomedical polymers
Polyalkylcyanoacrylate nanoparticles
Type of item
Journal Article (Published)
Abstract: Purpose: The aim of this work was to prepare poly n-butylcyanoacrylate (PNBCA) nanocapsules loaded with indomethacin and to evaluate the ability of this carrier system to deliver the drug systemically after its topical application. Methods: Poly n-butylcyanoacrylate (PNBCA) nanocapsules of indomethacin were prepared by interfacial polymerization. The physicochemical characterization of the PNBCA nanocapsules was performed by measuring the drug content by HPLC and analyzing the particle size using scanning electron microscopy. The in vitro permeation of indomethacin through excised rat skin and an artificial membrane was determined for PNBCA nanocapsules in pH 7.4 phosphate buffer (1), and in PLF-127 gel (II) and were compared against indomethacin incorporated into 25%w/w Pluronic F-127 (PLF-127) gel alone (III). The in vivo percutaneous absorption of indomethacin following the application of the PNBCA nanocapsules and a 25%w/w PLF-127 gel (111) was monitored by the determination of drug plasma levels in rats. RESULTS: The drug loading results indicated that similar to76.6% of indomethacin was loaded onto the PNBCA nanocapsules; the average particle size was 188 nm. The in vitro results indicated a rank order for the three formulations (1, II and 111) in both the flux at steady state and the cumulative amounts permeated at 8 hrs. The higher drug plasma levels over 6 hrs of indomethacin PNBCA nanocapsules are in agreement with the determined in vitro permeation results. Conclusion: The presented data show that indomethacin loaded PNBCA nanocapsules can improve the transdermal delivery of indomethacin compared to a conventional gel formulation using Pluronic F-127. This might be due to their ultra fine particle size and their hydrophilic and hydrophobic surface characteristics.
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This work is made available under the terms of the Creative Commons Attribution - Share Alike 3.0 Unported license,
Citation for previous publication
Shozo Miyazaki, Akie Takahashi, Wataru Kubo, John Bachynsky, Raimar Löbenberg. (2003). Poly n-butylcyanoacrylate (PNBCA) nanocapsules as a carrier for NSAIDs: in vitro release and in vivo skin penetration. J Pharm Pharm Sci, 6(2), 238-245.
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