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Permanent link (DOI): https://doi.org/10.7939/R3D90P

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Novel Alterations of Morphology and Genome of Mitochondria of Cholangiocellular Carcinoma Open Access

Descriptions

Other title
Subject/Keyword
mtDNA
Cholangiocarcinoma
Mitochondrial dysfunction
MitoChip
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Bahitham, Wesam Ahmad
Supervisor and department
Bamforth, Fiona (Department of Laboratory Medicine and Pathology)
Sergi, Consolato (Department of Laboratory Medicine and Pathology and Department of Pediatrics)
Examining committee member and department
Chan, Alicia (Department of Genetics)
Basu, Urmila (Department of Agricultural, Food and Nutritional Sciences)
Department
Medical Sciences- Laboratory Medicine and Pathology
Specialization

Date accepted
2013-01-30T13:43:11Z
Graduation date
2013-06
Degree
Master of Science
Degree level
Master's
Abstract
Cholangiocellular carcinoma (CCA) is the second most common hepatic malignancy, but its carcinogenesis is poorly understood. Somatic mitochondrial DNA (mtDNA) mutations have been demonstrated in a variety of human cancers. However, no study has previously investigated mitochondria and their genome alterations in CCA. Our findings suggest that mtDNA alterations are an important event during the carcinogenesis of CCA. In comparison with normal cell lines and other liver malignancies, both morphologic and functional changes of mitochondria and mitochondrial genome point to a striking result that may play a major role in the aggressiveness of CCA.
Language
English
DOI
doi:10.7939/R3D90P
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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Last modified: 2015:10:12 19:53:36-06:00
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File title: Microsoft Word - wesam's final thesis- sergi-MSc.doc
File author: Wesam Bahitham
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