Novel Alterations of Morphology and Genome of Mitochondria of Cholangiocellular Carcinoma

• Author / Creator

  Bahitham, Wesam Ahmad

• Cholangiocellular carcinoma (CCA) is the second most common hepatic malignancy, but its carcinogenesis is poorly understood. Somatic mitochondrial DNA (mtDNA) mutations have been demonstrated in a variety of human cancers. However, no study has previously investigated mitochondria and their genome alterations in CCA.
  Our findings suggest that mtDNA alterations are an important event during the carcinogenesis of CCA. In comparison with normal cell lines and other liver malignancies, both morphologic and functional changes of mitochondria and mitochondrial genome point to a striking result that may play a major role in the aggressiveness of CCA.

• Subjects / Keywords

  • Mitochondrial dysfunction
  • MitoChip
  • MtDNA
  • Cholangiocarcinoma

• Graduation date

  Spring 2013

• Type of Item

  Thesis

• Degree

  Master of Science

• DOI

  https://doi.org/10.7939/R3D90P

• License

  This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.