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Permanent link (DOI): https://doi.org/10.7939/R3PW4J

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The role of ezetimibe and simvastatin in modulating intestinal cholesterol transport, chylomicron profile and chylomicron-remnant uptake by the arterial wall in a rodent model of the metabolic syndrome Open Access

Descriptions

Other title
Subject/Keyword
atherosclerosis
apoB48
Simvastatin
cardiovascular disease
cholesterol
Ezetimibe
intestine
JCR:LA-cp rat
enterocyte
metabolic syndrome
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Warnakula, Samantha
Supervisor and department
Proctor, Spencer (Agricultural, Food and Nutritional Science)
Vine, Donna (Agricultural, Food and Nutritional Science)
Examining committee member and department
Thomson, Alan (Medicine)
Vine, Donna (Agricultural, Food and Nutritional Science)
Proctor, Spencer (Agricultural, Food and Nutritional Science)
Department
Department of Agricultural, Food, and Nutritional Science
Specialization

Date accepted
2010-08-31T21:17:57Z
Graduation date
2010-11
Degree
Master of Science
Degree level
Master's
Abstract
Intestinally derived chylomicron remnants (CM-r) may contribute to atherogenic dyslipidemia during the Metabolic Syndrome (Mets). However, the combined effects of ezetimibe (EZ) and simvastatin (SV) on post-prandial (PP) dyslipidemia during MetS remains unclear, nor is it known whether the combination has a synergistic anti-atherogenic effect on CM-r arterial retention. The first objective was to delineate the effects of EZ+SV therapy on intestinal cholesterol flux and CM PP metabolism in the JCR:LA-cp rat, a model of MetS. The second objective was to quantify the impact of EZ+SV therapy on arterial retention of CM-r and subsequent myocardial lesion development in the JCR:LA-cp rat. EZ+SV therapy decreased net intestinal cholesterol absorption in MetS rats. Furthermore, EZ+SV therapy reduced arterial retention of CM-r and frequency of myocardial lesions in MetS rats. In conclusion, EZ+SV therapy reduces arterial retention of CM-r and myocardial lesion development possibly through its beneficial effects on cholesterol transport and PP-metabolism.
Language
English
DOI
doi:10.7939/R3PW4J
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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