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Permanent link (DOI): https://doi.org/10.7939/R3GT27

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Measurement properties of primary outcome measures in pediatric RCTs: inadequate reporting, insufficient validation, or both? Open Access

Descriptions

Other title
Subject/Keyword
validation
primary outcome
reporting
measurement properties
outcome measure
pediatric RCTs
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Bhaloo, Zafira K
Supervisor and department
Vohra, Sunita (Pediatrics)
Examining committee member and department
Terwee, Caroline B (Epidemiology and Biostatistics)
Hartling, Lisa (Pediatrics)
Department
Medical Sciences-Paediatrics
Specialization
Medical Sciences - Paediatrics
Date accepted
2013-07-23T13:36:40Z
Graduation date
2013-11
Degree
Master of Science
Degree level
Master's
Abstract
Randomized controlled trials (RCTs) are the gold standard for high quality evidence generation pertaining to treatment effectiveness. RCT results are used in knowledge synthesis and evidence-based practice. The validity of RCT results is dependent upon the validity of the primary outcome measures. Primary outcomes and the measurement properties of the primary outcome measures should be clearly reported to enable confident interpretation of results. A systematic review of pediatric RCTs published in high impact journals found inadequate reporting of primary outcomes and the measurement properties of their outcome measures. Furthermore, quality assessments of the measurement properties and the methodology of the studies in which the properties are evaluated suggest a need for further validation. The issue is thus twofold: inadequate reporting paired with insufficient validation. The awareness of this dual issue can encourage higher reporting standards and improved conduct of trials to ultimately enhance the quality of primary research.
Language
English
DOI
doi:10.7939/R3GT27
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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