ERA

Download the full-sized PDF of MODELING INCOMPLETE CERVICAL SPINAL CORD INJURY IN RATS TO EXPLORE MECHANISMS OF REHABILITATIVE TRAININGDownload the full-sized PDF

Analytics

Share

Permanent link (DOI): https://doi.org/10.7939/R3251FT54

Download

Export to: EndNote  |  Zotero  |  Mendeley

Communities

This file is in the following communities:

Graduate Studies and Research, Faculty of

Collections

This file is in the following collections:

Theses and Dissertations

MODELING INCOMPLETE CERVICAL SPINAL CORD INJURY IN RATS TO EXPLORE MECHANISMS OF REHABILITATIVE TRAINING Open Access

Descriptions

Other title
Subject/Keyword
Rehabilitation
Protein Kinase A
Animal models
Spinal cord injury
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Hurd, Caitlin L
Supervisor and department
Fouad, Karim (Rehabilitation Medicine)
Examining committee member and department
Gorassini, Monica (Biomedical Engineering)
Smith, Peter (Pharmacology)
Ali, Declan (Biological Sciences)
Bennett, David (Rehabilitation Medicine)
Department
Centre for Neuroscience
Specialization

Date accepted
2013-08-26T10:57:16Z
Graduation date
2013-11
Degree
Master of Science
Degree level
Master's
Abstract
Although limited functional recovery is observed following spinal cord injury (SCI), the most successful approach to promote recovery to date has been rehabilitative training. However, the effects of training are not stunning. With a thorough understanding of the intracellular mechanisms involved in training- induced recovery as well as a re-evaluation of the animal models used, it may be possible to enhance training efficacy following SCI. This thesis describes a study in which the cyclic AMP/protein kinase A intracellular signaling pathway was inhibited throughout rehabilitative reaching training in a rat model of incomplete cervical SCI to characterize its role in training-induced recovery. Additionally, a re-evaluation of a single pellet skilled reaching test is described in which an animal model of rehabilitative training and reaching recovery is analyzed. These data contribute to our understanding of rehabilitative training in animal models of SCI and may lead to greater improvements in this treatment approach.
Language
English
DOI
doi:10.7939/R3251FT54
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
Hurd C., Weishaupt N., Fouad K. (2013) Anatomical correlates of reaching recovery following incomplete cervical lesions of the rat spinal cord. Experimental Neurology.

File Details

Date Uploaded
Date Modified
2014-04-30T22:11:55.752+00:00
Audit Status
Audits have not yet been run on this file.
Characterization
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 10641582
Last modified: 2015:10:12 16:28:56-06:00
Filename: Hurd_Caitlin_Fall 2013.pdf
Original checksum: a8ef8934db1a91540de4b725202ada6c
Well formed: false
Valid: false
Status message: Invalid page tree node offset=9413546
Status message: Unexpected error in findFonts java.lang.ClassCastException: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject cannot be cast to edu.harvard.hul.ois.jhove.module.pdf.PdfDictionary offset=10634179
Status message: Outlines contain recursive references.
File title: Prefatory Pages August 2013
Page count: 93
Activity of users you follow
User Activity Date