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Permanent link (DOI): https://doi.org/10.7939/R39100

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Skeletal muscle fat infiltration is reversed by dietary fish oil in an animal model of colorectal cancer receiving irinotecan and 5-fluorouracil Open Access

Descriptions

Other title
Subject/Keyword
fatty muscle
myosteatosis
fish oil
docosahexanoic acid
eicosapentaenoic acid
cancer-associated fatty atrophy
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Giles, Kaitlin H
Supervisor and department
Dr. Vera Mazurak (Agricultural, Food & Nutritional Sciences)
Examining committee member and department
Dr. Vickie Baracos (Department of Oncology)
Dr. Carla Prado (Agricultural, Food & Nutritional Sciences)
Dr. Ted Putman (Physical Education and Recreation)
Department
Department of Agricultural, Food, and Nutritional Science
Specialization
Nutrition & Metabolism
Date accepted
2014-09-29T10:30:28Z
Graduation date
2014-11
Degree
Master of Science
Degree level
Master's
Abstract
This study aimed to assess the effect of a Ward colorectal tumour, and irinotecan + 5-fluorouracil after 1- or 2-cycles in rats fed a diet with or without fish oil (FO), on the amount and types of fatty acids in rat skeletal muscle. Upon chemotherapy initiation, rats remained on control diet or began FO diet. Gastrocnemius muscles were isolated before tumour implantation, before chemotherapy, and after 1- and 2-cycles. Triglyceride (TG) and phospholipid (PL) fatty acids (FAs) were extracted, separated, and quantified. Compared to healthy rats, tumour-bearing rats exhibited higher TG-FA content. After 1-cycle, FO-fed rats exhibited lower TG-FA content compared to tumour-bearing rats. Compared to control-feeding, FO-feeding resulted in lower TG-FA after both 1- and 2-cycles. N-3 FA content in muscle TG-FA and PL-FA was higher in FO group compared to control-fed. This study suggests that FO fed during chemotherapy may attenuate tumour- and chemotherapy-associated skeletal muscle TG-FA infiltration.
Language
English
DOI
doi:10.7939/R39100
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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