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Permanent link (DOI): https://doi.org/10.7939/R3445HM6J

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Development of a non-viral delivery system for siRNA for treatment of lymphoma Open Access

Descriptions

Other title
Subject/Keyword
lymphoma
PEI
polymeric carrier
non-viral
delivery
silencing
siRNA
cancer
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Sahin,B
Supervisor and department
Uludag, Hasan (Chemical and Materials Engineering)
Examining committee member and department
Weinfeld, Michael (Experimental Oncology)
Lavasanifar, Afsaneh (Pharmacy and Pharmaceutical Sciences)
Department
Department of Biomedical Engineering
Specialization
Biomedical sciences
Date accepted
2013-07-11T15:48:33Z
Graduation date
2013-11
Degree
Master of Science
Degree level
Master's
Abstract
The aim of this work is to develop an effective non-viral carrier and to identify suitable gene targets that would induce apoptosis specifically in lymphoma cells upon down-regulation with short interfering RNA (siRNA). Lymphoma is common in children and young adults, and although survival rate is high, the short and long-term effects of conventional drug therapy constitute a major problem in patients’ adult life. The use of siRNA and polymer-based carriers as a treatment for cancer is hypothesized to reduce the negative effects of drug treatment while increasing the survival rate.
Language
English
DOI
doi:10.7939/R3445HM6J
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File title: Microsoft Word - Sahin_Basak_MSc_Thesis_MW-HU-revised.docx
File author: Basak Sahin
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