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Permanent link (DOI): https://doi.org/10.7939/R3WM6D

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Effects of α-tocopherol supplementation on dexamethasone-induced insulin resistance Open Access

Descriptions

Other title
Subject/Keyword
AMPK
tocopherol
insulin resistance
glucose clearance
dexamethasone
glucocorticoid
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Williams, Deon
Supervisor and department
Wright, David (Agricultural, Food and Nutritional Science)
Examining committee member and department
Boule, Normand (Physical Education and Recreation)
Field, Catherine (Agricultural, Food and Nutritional Science)
Department
Department of Agricultural, Food and Nutritional Science
Specialization

Date accepted
2010-08-31T20:55:09Z
Graduation date
2010-11
Degree
Master of Science
Degree level
Master's
Abstract
This study aimed to examine potential mechanisms for glucocorticoid (GC)-induced decreases in glucose clearance, and to determine if a reduction in oxidative stress load via dietary pre-treatment with an antioxidant-rich diet has a positive net effect on glucose tolerance following a sub-chronic treatment with the GC analogue dexamethasone (DEX). Rats fed a diet supplemented with 700IU of α-tocopherol for two weeks had improved glucose clearance after five days of DEX-treatment relative to unsupplemented rats as well as decreased markers of oxidative stress. Following an intraperitoneal bolus of insulin, phosphorylation of AMP activated protein kinase (AMPK) was preserved in the supplemented groups despite no significant differences in upstream insulin signalling cascade intermediates between DEX-treated groups. This was corroborated by a similar increase (p<0.05) in phosphorylation of the downstream AMPK substrate acetyl CoA carboxylase. This study demonstrated that α-tocopherol supplementation can attenuate GC-induced decreases in glucose clearance in an AMPK-dependent manner.
Language
English
DOI
doi:10.7939/R3WM6D
Rights
License granted by Deon Williams (deon@ualberta.ca) on 2010-08-31T19:02:23Z (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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