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Permanent link (DOI): https://doi.org/10.7939/R35H7C145

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Maternal Early Life Adversity and Next Generation Wheeze and Allergy Open Access

Descriptions

Other title
Subject/Keyword
pregnancy
HPA axis programming
maternal
intergenerational transmission
childhood adversity
allergies
wheeze
child abuse
stress
immune system
trauma
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Pawlowski, Alicia N.
Supervisor and department
Dr. Anita Kozyrsky (Paediatrics)
Examining committee member and department
Dr Jacqueline Pei (Educational Psychology)
Dr. Lionel Dibden (Paediatrics)
Dr. Sandra Wiebe (Psychology)
Department
Medical Sciences-Paediatrics
Specialization
Medical Sciences-Paediatrics
Date accepted
2013-12-23T11:58:47Z
Graduation date
2014-06
Degree
Master of Science
Degree level
Master's
Abstract
Chronic trauma in childhood can program an abnormal stress reaction, resulting in lifelong difficulties with stress management and poor health outcomes linked to changes in the immune system. At the same time, maternal stress during pregnancy has been linked to childhood asthma. Given the potential for a mother’s early life maltreatment to shape her later response to stress during pregnancy, we hypothesized that preschoolers would be more likely to have a wheeze or allergic disorder if their mother has a history of adversity. We found a significant positive association between a mother’s early experience of household dysfunction and childhood wheeze. Maternal childhood psychological abuse was associated with children’s allergies. In summary, stressful maternal childhood experiences are associated with the development of wheeze and allergy in children. These findings emphasize the necessity of services aimed at lowering the stress of new mothers and the value of inquiring about early life experiences.
Language
English
DOI
doi:10.7939/R35H7C145
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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