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Permanent link (DOI): https://doi.org/10.7939/R3CB13

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Profiles of Systemic Inflammatory Response Indicated by C-reactive protein in Children Undergoing Ventricular Assist Device Support and Heart Transplantation Open Access

Descriptions

Other title
Subject/Keyword
Pediatrics
Ventricular Assist Device
C-reactive protein
Heart Transplantation
systemic Inflammatory Response
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Yu, Xiaoyang
Supervisor and department
West, Lori (Pediatrics)
Examining committee member and department
Cheung, Po-Yin (Paediatrics, Pharmacology)
West, Lori (Paediatrics)
Wang, Shaohua (Surgery)
Persad, Sujata (Paediatrics)
Department
Medical Sciences-Paediatrics
Specialization

Date accepted
2013-01-08T15:02:51Z
Graduation date
2013-06
Degree
Master of Science
Degree level
Master's
Abstract
C-reactive protein (CRP) is a biomarker of systemic inflammatory response (SIR) which is associated with the extent and activity of disease. The profiles of SIR and the changes of CRP remain unknown in children undergoing ventricular assist device (VAD) support and heart transplantation (HTx). We examined the perioperative measurements of CRP and the clinical implications in children undergoing VAD support and HTx. Preoperative CRP levels were elevated in both groups due to the mechanical circulatory support prior to surgery. VAD implantation was associated with a prolonged SIR, which may also influenced by an insufficient hemodynamics. The SIR was more pronounced in children receiving bi-ventricular than left-ventricular support. HTx induced an intensified SIR, which may be associated with longer cardiopulmonary bypass duration and insufficient hemodynamics. CRP did not predict the length of stay in the intensive care unit or hospital or death in children undergoing VAD support and HTx.
Language
English
DOI
doi:10.7939/R3CB13
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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