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Permanent link (DOI): https://doi.org/10.7939/R3J38KV61

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J-Coupling Effects on Quantification of the 1.3 ppm Lipid Methylene Resonance with In-Vivo Magnetic Resonance Spectroscopy at 3 T Open Access

Descriptions

Other title
Subject/Keyword
lipids
quantification
MRS
J-coupling
NMR
methylene
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Breitkreutz, Dylan Y
Supervisor and department
Yahya, Atiyah (Department of Oncology)
Examining committee member and department
Yahya, Atiyah (Oncology)
deZanche, Nicola (Oncology)
Fallone, B Gino (Oncology)
Thompson, Richard (Biomedical Engineering)
Department
Department of Oncology
Specialization
Medical Physics
Date accepted
2015-09-08T09:31:15Z
Graduation date
2015-11
Degree
Master of Science
Degree level
Master's
Abstract
Quantification of 1.3 ppm lipid methylene protons by proton magnetic resonance spectroscopy has been shown to be relevant to a number of diseases. Additionally, T2 estimation of 1.3 ppm methylene protons has been used to grade the metastatic potential of colon tumours. J-coupling interactions of lipid protons result in time dependent signal modulations. J-coupling effects can hinder quantification and T2 determination. The objective of the work presented in this thesis is to investigate the effects J-coupling on quantification and T2 estimation of 1.3 ppm lipid methylene protons by using a modified PRESS sequence to rewind the J-coupling evolution. The effects of J-coupling on quantification and T2 determination are studied by comparing the response of fatty acid phantoms and the tibial bone marrow of six volunteers to a standard PRESS sequence and to a modified PRESS sequence, which is designed to rewind J-coupling evolution. The work demonstrates that the consequence of neglecting to consider J-coupling effects on the quantification of 1.3 ppm lipid methylene protons and on their T2 values is not negligible.
Language
English
DOI
doi:10.7939/R3J38KV61
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
A version of chapter 3 has been accepted for publication.Dylan Breitkreutz, B. Gino Fallone, Atiyah Yahya, “Effect of J coupling on 1.3-ppm lipid methylene signal acquired with localised proton MRS at 3 T”, NMR in Biomedicine.

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