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Permanent link (DOI): https://doi.org/10.7939/R31S6C

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Influenza Vaccination in Solid Organ Tranplant Recipients Open Access

Descriptions

Other title
Subject/Keyword
Solid Organ Transplant
Influenza
Vaccination
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Baluch, Aliyah
Supervisor and department
Deepali Kumar, MD (Transplant Infectious Diseases)
Examining committee member and department
Atul Humar, MD (Transplant Inectious Diseases)
Patricia Campbell, MD (Transplant Nephrology)
Simon Urschel, MD (Pediatric Transplant Cardiology)
Department
Department of Medicine
Specialization
Experimental Medicine
Date accepted
2012-12-18T14:41:16Z
Graduation date
2013-06
Degree
Master of Science
Degree level
Master's
Abstract
Immunogenicity of intramuscular influenza vaccine is suboptimal in organ transplant recipients although intradermal vaccine may be superior by targeting dermal dendritic cells to stimulate a response. 229 patients were randomized to IM or high-dose ID vaccine during the 2010-11 season. Pre- and 1 month post-vaccine bloodwork measured serology by hemagglutination inhibition assay (for influenza A/H1N1, A/H3N2 and B strains) and HLA antibody. Seroconversion was defined as a 4-fold rise in titer. Median time from transplant was 4.9 years. In 212 evaluable patients (105 IM, 107 ID), seroconversion to at least one antigen was 46.7% & 51.4% respectively (p=0.5). Seroconversion to at least 1 antigen was greater if i) ≥ 6 months post-transplant (53.2% vs. 19.2%; p=0.001) or ii) on <2g of mycophenolate mofetil (60.0% vs. 36.7%; p=0.001). Our study suggests that intradermal vaccine is safe, may be more immunogenic in selected subgroups and does not increase clinically relevant HLA antibody.
Language
English
DOI
doi:10.7939/R31S6C
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
Baluch A, Humar A, Egli A, et al. Long Term Immune Responses to Pandemic Influenza A/H1N1 Infection in Solid Organ Transplant Recipients. PLoS One 2011;6(12):e28627.

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