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Intracranial Pressure Changes in Rat Models of Intracerebral Hemorrhage Open Access


Other title
Intracerebral Hemorrhage
Intracranial Pressure
Type of item
Degree grantor
University of Alberta
Author or creator
Hiploylee, Carmen
Supervisor and department
Colbourne, Fred (Psychology)
Examining committee member and department
Dickson, Clayton (Psychology)
Treit, Dallas (Psychology)
Butcher, Ken (Medicine)
Colbourne, Fred (Psychology)
Department of Psychology

Date accepted
Graduation date
Master of Science
Degree level
Intracerebral hemorrhage (ICH) is a devastating subtype of stroke but the role of increased intracranial pressure (ICP) in ICH is unclear - especially since most studies measure ICP in rodents tethered or under anesthesia or restraint. Thus, ICP was measured using telemetry in untethered, awake rats after ICH for 4 days. In PART 1, no pressure differences were found between the site of injury and epidural space. In PART 2, a severe ICH increased ICP for 4 days with modest reductions in cerebral perfusion pressure. In PART 3, moderate to severe ICHs were compared in different models of ICH. When ICH was induced by a collagenase infusion, ICP was increased for 2 days. However, ICP did not increase when the ICH was induced by a whole blood infusion. Lastly, increases in edema correlated with increases in ICP. These findings demonstrate ICH model differences that must be considered when evaluating therapies.
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