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Permanent link (DOI): https://doi.org/10.7939/R3707WX11

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Intracranial Pressure Changes in Rat Models of Intracerebral Hemorrhage Open Access

Descriptions

Other title
Subject/Keyword
Intracerebral Hemorrhage
Intracranial Pressure
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Hiploylee, Carmen
Supervisor and department
Colbourne, Fred (Psychology)
Examining committee member and department
Dickson, Clayton (Psychology)
Treit, Dallas (Psychology)
Butcher, Ken (Medicine)
Colbourne, Fred (Psychology)
Department
Department of Psychology
Specialization

Date accepted
2013-08-23T15:37:03Z
Graduation date
2013-11
Degree
Master of Science
Degree level
Master's
Abstract
Intracerebral hemorrhage (ICH) is a devastating subtype of stroke but the role of increased intracranial pressure (ICP) in ICH is unclear - especially since most studies measure ICP in rodents tethered or under anesthesia or restraint. Thus, ICP was measured using telemetry in untethered, awake rats after ICH for 4 days. In PART 1, no pressure differences were found between the site of injury and epidural space. In PART 2, a severe ICH increased ICP for 4 days with modest reductions in cerebral perfusion pressure. In PART 3, moderate to severe ICHs were compared in different models of ICH. When ICH was induced by a collagenase infusion, ICP was increased for 2 days. However, ICP did not increase when the ICH was induced by a whole blood infusion. Lastly, increases in edema correlated with increases in ICP. These findings demonstrate ICH model differences that must be considered when evaluating therapies.
Language
English
DOI
doi:10.7939/R3707WX11
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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