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Permanent link (DOI): https://doi.org/10.7939/R38P6H

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Assessing outcome after hyperthermia in a rat model of intracerebral hemorrhage Open Access

Descriptions

Other title
Subject/Keyword
Fever
Striatum
Temperature
Intracerebral hemorrhage
Rat
Hyperthermia
Stroke
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Penner, Mark
Supervisor and department
Dr. Fred Colbourne (Psychology)
Examining committee member and department
Dr. Chris Sturdy (Psychology)
Dr. Ken Butcher (Neurology)
Department
Department of Psychology
Specialization

Date accepted
2010-09-29T20:43:31Z
Graduation date
2010-11
Degree
Master of Science
Degree level
Master's
Abstract
Hyperthermia worsens outcome after ischemia. While it seems reasonable that hyperthermia would also worsen outcome after intracerebral hemorrhage (ICH), clinical studies attempting to find a causative relationship between hyperthermia and outcome have been inconclusive. We induced ICH with an injection of autologous whole blood (100 μl) immediately followed by 3 hours of hyperthermia (HYPER; 39°C) or normothermia (NORMO; 37°C). Surprisingly, hyperthermia reduced edema at 72 hours, and improved outcome on day 3 post-ICH. There were no behavioural differences at later time points (day 11 and 32 post-ICH) and no difference in lesion volume (NORMO 14.0 mm3, HYPER: 14.5 mm3). Overall, this study does not support the hypothesis that mild, transient hyperthermia worsens outcome after ICH. Further research is needed to determine if more severe or prolonged hyperthermia worsens outcome, or if the cause of hyperthermia (e.g. infection) is important.
Language
English
DOI
doi:10.7939/R38P6H
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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