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Permanent link (DOI): https://doi.org/10.7939/R3HH7B

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Novel roles for zebrafish Sfrp1a and Sfrp5 in neural retina patterning Open Access

Descriptions

Other title
Subject/Keyword
secreted frizzled-related protein
eye
retina
zebrafish
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Holly, Vanessa L
Supervisor and department
Waskiewicz, Andrew (Biological Sciences)
Examining committee member and department
Ali, Declan (Biological Sciences)
Lehmann, Ordan (Ophthalmology & Medical Genetics)
Department
Department of Biological Sciences
Specialization
Molecular Biology & Genetics
Date accepted
2012-08-08T14:49:30Z
Graduation date
2012-11
Degree
Master of Science
Degree level
Master's
Abstract
Sensory systems are complex structures that receive stimuli from the surrounding environment and convert them into interpretable information. In the visual system, light hitting the eye is transmitted to the brain in a way that preserves the spatial conformation of the pictures we see. Retinal ganglion cells are given directional cues of where to innervate the brain, based on the unique cohort of genes activated during retinal development. If there are alterations in gene expression, it can result in aberrant axon projection to the brain and improper choroid fissure closure (ocular coloboma). Using zebrafish as a model system, I demonstrate that Sfrp1a (Secreted frizzled-related protein) and Sfrp5 work cooperatively to establish dorsal retinal identity by facilitating signaling from two well known dorsal retina specification pathways, bone morphogenic protein (BMP) and Wnt. Previous experiments identify Sfrps as BMP inhibitors, revealing a novel, positive interaction between Sfrps and BMPs.
Language
English
DOI
doi:10.7939/R3HH7B
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
Gongal, P.A., March, L.D., Holly, V.L., Pillay, L.M., Berry-Wynne, K.M., Kagechika, H., Waskiewicz, A.J. (2011) Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning. Developmental Biology 355:55-64.

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