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Permanent link (DOI): https://doi.org/10.7939/R3S382

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An Improved 3D In Vitro Model for High-throughput Electrode Biocompatibility Testing Open Access

Descriptions

Other title
Subject/Keyword
Astrocytes
Neural Interfacing
Hyaluronic acid
Hydrogels
Microglia
3D Culture
Biocompatibility
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Jeffery, Andrea F
Supervisor and department
Elias, Anastasia (Chemical and Materials Engineering)
Todd, Kathryn (Psychiatry)
Examining committee member and department
Unsworth, Larry (Chemical and Materials Engineering)
Department
Department of Chemical and Materials Engineering
Specialization
Materials Engineering
Date accepted
2014-01-21T15:54:17Z
Graduation date
2014-06
Degree
Master of Science
Degree level
Master's
Abstract
Recent technological advancements in the field of neural recording and decoding have changed the landscape of neural prostheses. However, a lack of biocompatible electrodes for long-term neural recording resulting in loss of electrode functionality is currently a major limiting factor for clinical implementation of advancing neural interfacing technology. Chronic activation of microglia and astrocytes as well as increasing cell density at the electrode are considered to be the primary reason for decreasing electrode functionality over time. Glial scarring models to date (primarily in vivo) have provided an excellent documentation of the temporal response of microglia and astrocytes upon electrode insertion, but do not satisfactorily address the degree to which various electrode parameters influence glial scarring. Herein a novel 3D glial scarring model based on hyaluronic acid is proposed. This model is shown to support mixed glial cells, mimic the mechanical properties of the central nervous system and model the acute inflammatory response over 21 days.
Language
English
DOI
doi:10.7939/R3S382
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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