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Permanent link (DOI): https://doi.org/10.7939/R3PT57

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The Role of Matrix Metalloproteinase-2 in the Pathophysiology of a Reduced Utero-Placental Perfusion Pressure Model of Preeclampsia Open Access

Descriptions

Other title
Subject/Keyword
Animal Model
Reduced Utero-Placental Perfusion Pressure
Matrix Metalloproteinase-2
Preeclampsia
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Abdalvand, Ali
Supervisor and department
Davidge, Sandra (Obstetrics and Gynecology / Physiology)
Examining committee member and department
Mitchel, Bryan(Peter) (Obstetrics and Gynecology / Physiology)
Chari, Radha (Obstetrics and Gynecology)
Kassiri, Zam (Physiology)
Department
Medical Sciences- Obstetrics and Gynecology
Specialization

Date accepted
2012-09-18T11:18:42Z
Graduation date
2012-09
Degree
Master of Science
Degree level
Master's
Abstract
Preeclampsia is a leading cause of maternal and fetal morbidity/mortality and induced preterm birth. Endothelin-1 (ET-1) is a potent vasoactive agent, shown to be involved in the vascular endothelial dysfunction of preeclampsia. Big endothelin (bigET) is cleaved to ET-1 by several enzymes including matrix metalloproteinase-2 (MMP-2). I hypothesized that increased levels and/or activity of MMP-2 may lead to enhanced production of ET-1 and thus increase vasoconstriction in preeclampsia. I used the reduced utero-placental perfusion pressure (RUPP) model of preeclampsia and studied vascular function using mesenteric arteries from Sham and RUPP to test my hypothesis. I showed that: 1) vascular contractility in response to bigET was greater in RUPP, 2) the contribution of MMP-2 to bigET to ET-1 cleavage was greater in RUPP, 3) nitric oxide can modulate the function of MMP-2 and several other bigET cleaving enzymes. These novel findings can provide avenues for new therapeutic approaches to preeclampsia.
Language
English
DOI
doi:10.7939/R3PT57
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
Lectin-like oxidized low-density lipoprotein 1 receptor in a reduced uteroplacental perfusion pressure rat model of preeclampsia.Morton JS, Abdalvand A, Jiang Y, Sawamura T, Uwiera RR, Davidge ST. Hypertension. 2012 May;59(5):1014-20. Epub 2012 Mar 5.

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