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Differential Expression of TWSG1, BMP4 and Shh Morphogens Signaling Proteins in Hepatocellular Carcinoma and Cholangiocellular Carcinoma Open Access


Other title
Hepatocellular carcinoma
Tumor markers
Cholangiocellular carcinoma
Type of item
Degree grantor
University of Alberta
Author or creator
Albahrani, Redha Mohammed
Supervisor and department
Sergi, Consolato (Department of Laboratory Medicine and Pathology and Department of Pediatrics)
Keelan, Monika (Department of Laboratory Medicine and Pathology)
Examining committee member and department
Persad, Sujata (Department of Pediatrics)
Bamforth, Fiona (Department of Laboratory Medicine and Pathology)
Martin, Jonathan (Department of Laboratory Medicine and Pathology)
Medical Sciences- Laboratory Medicine and Pathology

Date accepted
Graduation date
Master of Science
Degree level
Hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CCA) constitute two of the most common liver malignancies in adults. The molecular mechanisms underlying their development remain poorly understood. Morphogen proteins, including the hedgehog and the bone morphogenetic proteins pathway fulfill a major role in embryonic development. Consequently, alterations in these proteins may cause embryonic defects. Furthermore, abnormal expression of morphogen proteins is found to correlate with cancer development and progression. This thesis has demonstrated the differential expression and co-localization of the morphogen proteins, including sonic hedgehog (Shh), bone morphogenetic protein (BMP)-4 and twisted gastrulation protein (TWSG)-1 in human HCC and CCA tumors and cell lines. These proteins are strongly expressed in CCA more than in HCC. Overall, these findings suggest that morphogen proteins may play a crucial role during liver carcinogenesis and progression, specifically in CCA. Moreover, these proteins can serve as diagnostic biomarkers for HCC and CCA.
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
Johnston, J., Al-Bahrani, R., Abuetabh, Y., Chiu, B., Forsman, C.L., Nagamori, S., Leng, R., Petryk, A. and Sergi, C. (2012). Twisted gastrulation expression in cholangiocellular and hepatocellular carcinoma. J. Clin. Pathol. 10, 945-948.

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