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Permanent link (DOI): https://doi.org/10.7939/R3S41R

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Evaluation of Concomitant Temozolomide Treatment in Glioblastoma Multiforme Patients in Two Canadian Tertiary Care Centers Open Access

Descriptions

Other title
Subject/Keyword
Glioblastoma multiforme GBM, Radiation Therapy RT
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Alnaami, Ibrahim
Supervisor and department
Mehta, Vivek (Neurosurgery)
Senthilselvan, Ambikaipakan (Public Health Sciences)
Examining committee member and department
O'Kelly, Cian (Neurosurgery)
Gourishankar, Sita (Public Health Sciences)
Department
Public Health Sciences
Specialization

Date accepted
2010-08-25T15:46:16Z
Graduation date
2010-11
Degree
Master of Science
Degree level
Master's
Abstract
The study evaluated the survival of 364 glioblastoma multiforme (GBM) patients who received different modalities of treatment in two Canadian tertiary care centres. Retrospective and prospective databases were utilized to do a retrospective population based cohort study. The thesis question was “among treated GBM patients in Edmonton and Halifax; does the survival rate differ with introduction of concomitant temozolomide and radiation therapy (RT) versus non concomitant treatment?” Our results indicate that concomitant temozolomide with radiation therapy and surgery was associated with longer survival in comparison to radiation therapy with surgery. We also found that age; surgical resection and shorter time to radiation therapy are important factors for longer survival.
Language
English
DOI
doi:10.7939/R3S41R
Rights
License granted by Ibrahim Alnaami (ialnaami@ualberta.ca) on 2010-08-06T02:19:46Z (GMT): Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of the above terms. The author reserves all other publication and other rights in association with the copyright in the thesis, and except as herein provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File title: intro.revivion july 2010
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