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Permanent link (DOI): https://doi.org/10.7939/R3V98031K

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Acid Labile Surfactants Containing Ketal-Linkage in Micellar Electrokinetic Chromatography and Electrospray Ionization Mass Spectrometry Open Access

Descriptions

Other title
Subject/Keyword
ALS
MEKC
ESI-MS
Surfactant
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Stanley, Bob
Supervisor and department
Lucy, Charles (Chemistry)
Examining committee member and department
Li, Liang (Chemistry)
Amirfazli, Alidad (Mechanical Engineering)
Department
Department of Chemistry
Specialization
Analytical
Date accepted
2012-07-09T15:34:10Z
Graduation date
2012-11
Degree
Master of Science
Degree level
Master's
Abstract
The combination of micellar electrokinetic chromatography (MEKC) with electrospray ionization mass spectrometry (ESI-MS) would yield a very powerful analytical technique. However, hyphenating both techniques is not easy. Sodium 4-[(2-methyl-2-undecyl-1,3-dioxolan-4-yl) methoxy]-1-propane sulfonate (ALS) and sodium 2,2-Bis(hexyloxy)propyl sulphate (OALS) are possible solutions to link MEKC with ESI-MS. They are surfactants that are hydrolyzable under acidic condition. Their hydrolysis products are compatible with ESI-MS. They can be utilized as pseudostationary phases to perform a separation and then acid-hydrolyzed before being introduced into the ESI-MS. Both surfactants are compared with sodium dodecyl sulphate (SDS). ALS and OALS offer different selectivity than SDS. In term of mobility, ALS has a slower mobility than SDS. OALS has a greater mobility than SDS. ALS contains a cyclic ketal while OALS contains an acyclic ketal. OALS hydrolyzes much faster than ALS. The hydrolysis can be slowed down by lowering the temperature and vice versa.
Language
English
DOI
doi:10.7939/R3V98031K
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
B. Stanley, C.A. Lucy, J. Chromatogr. A, 1226 (2012) 55.

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