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Permanent link (DOI): https://doi.org/10.7939/R35C9M

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Associative plasticity and afferent regulation of corticospinal excitability in uninjured individuals and after incomplete spinal cord injury Open Access

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Other title
Subject/Keyword
human
peripheral nerve stimulation
spinal cord injury
intracortical inhibition
transcranial magnetic stimulation
motor cortex
tibialis anterior muscle
corticospinal tract
leg
plasticity
motor evoked potential
sensory input
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Roy, Francois D.
Supervisor and department
Gorassini, Monica A. (Biomedical Engineering; Centre for Neuroscience)
Examining committee member and department
Chan, K. Ming (Division of Physical Medicine and Rehabilitation; Centre for Neuroscience)
Jones, Kelvin E. (Physical Education and Recreation Faculty; Centre for Neuroscience)
Stein, Richard B (Department of Physiology; Centre for Neuroscience)
Chen, Robert (Division of Neurology and Department of Medicine; University of Toronto)
Collins, David F. (Physical Education and Recreation Faculty; Centre for Neuroscience)
Department
Department of Biomedical Engineering
Specialization

Date accepted
2009-09-18T15:24:46Z
Graduation date
2009-11
Degree
Doctor of Philosophy
Degree level
Doctoral
Abstract
Cortical representations are plastic and are allocated based on the proportional use or disuse of a pathway. A steady stream of sensory input maintains the integrity of cortical networks; while in contrast, alterations in afferent activation promote sensorimotor reorganization. After an incomplete spinal cord injury (SCI), damage to the ascending and/or descending pathways induces widespread modifications to the sensorimotor system. Strengthening these spared sensorimotor pathways may be therapeutic by promoting functional recovery after injury. Using a technique called transcranial magnetic stimulation (TMS), we show that the leg motor cortex is facilitated by peripheral sensory inputs via disinhibition and potentiation of excitatory intracortical circuits. Hence, in addition to its crucial role in sensory perception, excitation from peripheral sensory afferents can reinforce muscle activity by engaging, and possibly shaping, the activity of the human motor cortex. After SCI, the amount of excitation produced by afferent stimulation reaching the motor cortex is expectantly reduced and delayed. This reduction of sensory inflow to the motor cortex may contribute to our findings that cortical inhibition is down-regulated after SCI, and this compensation may aid in the recruitment of excitatory networks in the motor cortex as a result of the damage to its output neurons. By repeatedly pairing sensory inputs from a peripheral nerve in the leg with direct cortical activation by TMS, in an intervention called paired associative stimulation, we show that the motor system can be potentiated in both uninjured individuals and after SCI. In the uninjured subjects, we show that in order to produce associative facilitation, the time window required for coincident activation of the motor cortex by TMS and peripheral sensory inputs is not as narrow as previously thought (~100 vs. ~20 ms), likely due to the persistent activation of cortical neurons following activation by TMS. The potential to condition the nervous system with convergent afferent and cortical inputs suggests that paired associative stimulation may serve as a priming tool for motor plasticity and rehabilitation following SCI.
Language
English
DOI
doi:10.7939/R35C9M
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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