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Permanent link (DOI): https://doi.org/10.7939/R3B61D

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1H-MRS Measurements of Brain Metabolites in Postpartum Depression and Pregnancy Open Access

Descriptions

Other title
Subject/Keyword
pregnant women
neuropsychiatric disorders
glutamate
postpartum depression
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Burgess, Denee
Supervisor and department
Le Mellédo, Jean-Michel (Psychiatry)
Examining committee member and department
Hanstock, Chris (Biomedical Engineering)
Baker, Glen (Psychiatry)
Department
Department of Psychiatry
Specialization

Date accepted
2012-05-30T13:16:02Z
Graduation date
2012-11
Degree
Master of Science
Degree level
Master's
Abstract
Numerous investigations have suggested that dysregulation of the neurotransmitter glutamate (Glu) plays an important role in certain neuropsychiatric disorders, like depression. Pregnancy and the postpartum period are associated with the most substantial physiological alteration of female hormones which may likely contribute to variations in Glu levels. The objective of this thesis project was to measure Glu levels in the medial prefrontal cortex in women with postpartum depression (PPD) and pregnant women. Using proton magnetic resonance spectroscopy at the field strength of 3 Tesla, we acquired single-voxel spectra from 16 patients with PPD, 15 healthy pregnant women near term and 13 healthy controls. A reduction in Glu levels was observed in PPD and pregnant women compared to healthy controls. Lower brain Glu levels may play a role in the pathophysiology of PPD and could contribute to the impact of a normal pregnancy on the course of certain neuropsychiatric disorders.
Language
English
DOI
doi:10.7939/R3B61D
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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