Transmission of Tuberculosis from Patients with Typical Versus Atypical Chest Radiographs: Implications for Automated Systems Open Access
- Other title
Computer aided detection systems
- Type of item
- Degree grantor
University of Alberta
- Author or creator
Lau, Angela S
- Supervisor and department
Long, Richard (Medicine)
- Examining committee member and department
Long, Richard (Medicine)
Dhawan, Vivek (Medicine)
Barrie, James (Radiology)
Department of Medicine
- Date accepted
- Graduation date
Master of Science
- Degree level
Automated detection of “typical” pulmonary tuberculosis (PTB) on chest radiograph (CXR) is warranted if it can be shown that patients with “typical” (vs “atypical”) CXRs are responsible for most public health consequences.
Patient demographics and mycobacteriology of all adults (age >14 years) diagnosed with smear-positive PTB in Alberta between January 1, 2006 to December 31, 2008 was abstracted. Pre-treatment CXRs were scored by 3 independent readers as “typical” (having an upper lung zone infiltrate, with or without cavitation, but no discernable adenopathy) or “atypical”.
A total of 97 smear-positive PTB cases were identified, of whom 69 (71.1 %) had a “typical” CXR. Patients with ‘typical’ CXRs had larger bacillary burdens and more metabolically active bacteria (larger semi-quantitative smears; shorter times-to-culture-positivity) than patients with “atypical” CXRs. Significantly, they are responsible for 78% of TST conversion and 95% of secondary cases.
PTB patients with “typical” CXRs are responsible for most public health consequences. Accordingly, the development of an automated TB detection system is warranted.
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