ERA

Download the full-sized PDF of Whole genome fine mapping of QTL for ultrasound and carcass merit traits in beef cattleDownload the full-sized PDF

Analytics

Share

Permanent link (DOI): https://doi.org/10.7939/R3SN0178Z

Download

Export to: EndNote  |  Zotero  |  Mendeley

Communities

This file is in the following communities:

Roy Berg Kinsella Research Ranch

Collections

This file is in the following collections:

Journal Articles (Kinsella Ranch)

Whole genome fine mapping of QTL for ultrasound and carcass merit traits in beef cattle Open Access

Descriptions

Author or creator
Nalaila, S.
Li, C.
Wang, Z.
Stothard, P.
Moore, S. S.
Additional contributors
Subject/Keyword
single nucleotide polymorphisms
quantitative trait loci
beef cattle
carcass merit
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Quantitative trait loci (QTL) mapped to large chromosomal regions have limited utility as DNA markers for marker-assisted selection (MAS) and are less informative as a reference for the identification of the underlying causative quantitative trait nucleotides (QTN). The objective of this study was to conduct a whole genome fine mapping of QTL for ultrasound and carcass merit traits in beef cattle using a greater density of single nucleotide polymorphism (SNP) markers, and to identify SNP markers within the QTL regions that are associated with the traits. A total of 418 steers from 28 sires were used in this study with nine ultrasound and seven carcass merit traits that were collected as part of a feedlot trial conducted from 2003 to 2005 at the University of Alberta Kinsella ranch. Sires and their progeny were genotyped for a total of 4592 SNP markers distributed across all 29 bovine autosomes (BTA). Across-family analyses detected 12 QTL for five ultrasound traits on nine chromosomes and 18 QTL for six carcass merit traits on 10 chromosomes (P<0.05). Within-family analyses identified 78 significant QTL for nine ultrasound and seven carcass merit traits (P<0.01). The use of a denser panel of SNP markers allowed fine mapping of QTL to smaller chromosomal regions ranging from 0.6 to 11 cM compared with relatively larger QTL regions of 4 to 24 cM reported in previous studies. Furthermore, single SNP marker association analyses identified 22 SNPs that were significantly associated with three ultrasound and four carcass merit traits under 12 QTL regions (P<0.05). These identified SNP markers significantly associated with the traits under the fine mapped QTL regions provide genomic tools for potential application of MAS and a reference to assist with the identification of QTN causing variations in ultrasound and carcass merit traits in beef cattle.
Date created
2011
DOI
doi:10.7939/R3SN0178Z
License information
Rights
@2011 Nalaila, S., Li, C., Wang, Z., Stothard, P., Moore, S. S. This version of this article is open access and can be downloaded and shared. The original author(s) and source must be cited.
Citation for previous publication
Nalaila, S., Li, C., Wang, Z.,Stothard, P. and Moore, S.S. (2011). Whole genome fine mapping of quantitative trait loci for ultrasound and carcass merit traits in beef cattle. Canadian Journal of Animal Science, 91(1), 61-73.  http://dx.doi.org/10.4141/CJAS10007

Source
Link to related item

File Details

Date Uploaded
Date Modified
Audit Status
Audits have not yet been run on this file.
Characterization
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 333935
Last modified: 2016:06:24 17:30:09-06:00
Filename: cjas_91(1)
Original checksum: 8122a14e58d3835bac0c8798e0d7374e
Well formed: false
Valid: false
Status message: Invalid page dictionary object offset=333133
File title: Whole genome fine mapping of quantitative trait loci for ultrasound and carcass merit traits in beef cattle
File author: Sungael Nalaila, Paul Stothard, Stephen Moore, Zhiquan Wang, Changxi Li
Activity of users you follow
User Activity Date