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Permanent link (DOI): https://doi.org/10.7939/R3MC8RV9X

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Effect of providing a formula supplemented with long chain polyunsaturated fatty acids on immunity in full term neonates Open Access

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Author or creator
Field, Catherine J.
van Aerde, John E.
Robinson, Lindsay E.
Clandinin, M. Thomas
Additional contributors
Subject/Keyword
Lymphocytes
Cytokines
Immunity
Mitogens
Development
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
To determine the effect of feeding formula containing long-chain PUFA (LCP) on immune function, healthy term infants were randomised at age 2 weeks to either a standard term formula (Formula; n 14) or the same formula supplemented with the LCP 20 : 4n-6 and 22 : 6n-3 (Formula+LCP; n 16). Peripheral blood was collected at 2 and 6 weeks to measure immune cell response (the rate of [3H]thymidine uptake and cytokine production after stimulation with phytohaemagglutinin (PHA)). Compared with cells from infants receiving only human milk (HM), the rate of [3H]thymidine uptake in response to PHA, but not IL-2 production, was lower for Formula+LCP infants (P < 0·05). Compared with HM-fed infants, Formula-fed infants (but not Formula+LCP infants) produced more TNF-α (unstimulated) and had a fewer CD3+CD44+ cells before stimulation and fewer CD11c+ cells post-stimulation (P < 0·05). However, compared with Formula-fed infants, the Formula+LCP infants had an immune cell distribution (higher percentage CD3+CD44+ and CD4+CD28+ cells) and cytokine profile (lower production of TNF-α post-stimulation) that did not differ from HM infants. Additionally, it was found that feeding infants formula during the first 10 d of life influenced immune function. These infants had a higher percentage of CD3+, CD4+CD28+, and lower percentage of CD14+ cells and produced more TNF-α and interferon-γ after PHA stimulation than HM-fed infants (P < 0·05). These results demonstrate that early diet influences both the presence of specific cell types and function of infant blood immune cells. Since many diseases have a strong immunological component, these immune changes may be of physiological importance to the developing infant.
Date created
2008
DOI
doi:10.7939/R3MC8RV9X
License information
© The Authors 2008
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Citation for previous publication
Field, C. J., van Aerde, J. E., Robinson, L. E., & Clandinin, M. T. (2008). Effect of providing a formula supplemented with long chain polyunsaturated fatty acids on immunity in full term neonates. British Journal of Nutrition, 99(1), 91-99.  http://dx.doi.org/10.1017/S0007114507791845

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