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Permanent link (DOI): https://doi.org/10.7939/R33F4M21M

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Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model Open Access

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Author or creator
Brown, Eric M.
Wlodarska, Marta
Willing, Benjamin P.
Vonaesch, Pascale
Han, Jun
Reynolds, Lisa A.
Arrieta, Marie-Claire
Uhrig, Marco
Scholz, Roland
Partida, Oswaldo
Borchers, Christoph H.
Sansonetti, Philippe J.
& Finlay, B. Brett
Additional contributors
Subject/Keyword
Malnutrition
Environmental Microbiology
Inflammatory Diseases
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Environmental enteropathy (EE) is a subclinical chronic inflammatory disease of the small intestine and has a profound impact on the persistence of childhood malnutrition worldwide. However, the aetiology of the disease remains unknown and no animal model exists to date, the creation of which would aid in understanding this complex disease. Here we demonstrate that early-life consumption of a moderately malnourished diet, in combination with iterative oral exposure to commensal Bacteroidales species and Escherichia coli, remodels the murine small intestine to resemble features of EE observed in humans. We further report the profound changes that malnutrition imparts on the small intestinal microbiota, metabolite and intraepithelial lymphocyte composition, along with the susceptibility to enteric infection. Our findings provide evidence indicating that both diet and microbes combine to contribute to the aetiology of EE, and describe a novel murine model that can be used to elucidate the mechanisms behind this understudied disease.
Date created
2015
DOI
doi:10.7939/R33F4M21M
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Attribution 4.0 International
Citation for previous publication
Brown, E. M., Wlodarska, M., Willing, B. P., Vonaesch, P., Han, J., Reynolds, L. A., Arrieta, M. -C., Uhrig, M., Scholz, R., Partida, O., Borchers, C. H., Sansonetti, P. J., & Finlay, B. B. (2015). Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model. Nature Communications, 6, 7806 [16 pages].  http://dx.doi.org/10.1038/ncomms8806

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File title: Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model
File author: Eric M. Brown
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