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Permanent link (DOI): https://doi.org/10.7939/R3VQ2SM82

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The relationship between metformin exposure, prostate cancer and race/ethnicity Open Access

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Other title
Subject/Keyword
metformin
prostate cancer
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Chen, Christopher B
Supervisor and department
Johnson, Jeffrey (Public Health)
Examining committee member and department
Eurich, Dean (Public Health)
Majumdar, Sumit (Medicine)
Lynd, Larry (Pharmacy)
Department
School of Public Health
Specialization
Clinical Epidemiology
Date accepted
2016-07-08T10:46:32Z
Graduation date
2016-06:Fall 2016
Degree
Master of Science
Degree level
Master's
Abstract
Relative to those without diabetes, individuals with type 2 diabetes have an increased risk of several cancers, but a decreased risk of prostate cancer. While metformin may reduce the risk of some cancers, it may not reduce the risk of prostate cancer. However, race/ethnicity may modify metformin’s effect. Thus, our objective was to investigate the impact of metformin exposure on prostate cancer risk in Western and Asian populations by conducting two studies: 1) a systematic review of published literature and 2) an retrospective cohort study. In our literature review, metformin was not associated with prostate cancer in either population. However, this study was limited by significant heterogeneity across published studies. Despite less heterogeneity, our cohort study further suggested that there is no relationship between metformin exposure, prostate cancer and race/ethnicity.
Language
English
DOI
doi:10.7939/R3VQ2SM82
Rights
This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for the purpose of private, scholarly or scientific research. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
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