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Permanent link (DOI): https://doi.org/10.7939/R3NM67

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The Impact of Sleeve Gastrectomy as compared to Adjustable Gastric Band on Active and Total Ghrelin and other GI Hormones and their influence on Satiety and Hunger Open Access

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Other title
Subject/Keyword
Satiety
Sleeve Gastrectomy
Ghrelin
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Almamar, Ahmed
Supervisor and department
Sharma, Arya (Medicine)
Birch, Daniel W (Surgery)
Examining committee member and department
Chan, Catherine (Physiology)
Churchill, Thomas (Surgery)
Haqq, Andrea (Pediatrics)
Department
Department of Surgery
Specialization
Experimental Surgery
Date accepted
2012-08-21T13:48:12Z
Graduation date
2012-11
Degree
Master of Science
Degree level
Master's
Abstract
Laparoscopic sleeve gastrectomy (LSG) is a relatively new bariatric procedure that has been proposed as a potential definitive treatment for morbid obesity. The mechanism of action of LSG remains unclear, but may include increased restriction to meal portion size, alterations in gastric emptying or increased satiety related to alterations in serum ghrelin (endogenous orexigenic hormone) or other active endogenous satiety hormones. Initial reports have suggested that LSG produces dramatic reductions in hunger and augmented satiety. However, the data on the effect of this procedure on satiety hormones and their influence on satiety and hunger are still limited. This project is a cross-sectional study of 30 matched obese patients following LSG (10), Laparoscopic Adjustable Gastric Banding (LAGB) and obese controls. Satiety hormones and satiety scores were analyzed after a standardized test meal. The result of this work showed that both active and total ghrelin were lower following LSG as compared to LAGB. Also, both PYY and GLP-1 were higher in the LSG cohort. These changes were associated with an improved satiety scores suggesting that LSG is a metabolic procedure that affects multiple gut hormones in a favorable way.
Language
English
DOI
doi:10.7939/R3NM67
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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File title: Thesis
File author: AHMED ALMAMAR
Page count: 113
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