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Single and combined supplementation of glutamine and n-3 polyunsaturated fatty acids on host tolerance and tumour response to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (CPT-11)/5-fluorouracil chemotherapy in rats bearing Ward colon tumour Open Access

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Author or creator
Xue, Hongyu
Le Roy, Severine
Sawyer, Michael B.
Field, Catherine J.
Dieleman, Levinus A.
Baracos, Vickie E.
Additional contributors
Subject/Keyword
Glutamine
CPT-11
n-3 PUFA
5-Fluorouracil
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Prior reports suggest that during irinotecan (7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin; CPT-11) chemotherapy in laboratory rats, the anti-tumour efficacy and diarrhoea toxicity could be modulated by n-3 PUFA and glutamine, respectively. We further examined how these two dietary elements, when provided individually and in combination, would affect the efficacy of a cyclical regimen of CPT-11/5-fluorouracil (5-FU), an accepted combination regimen for colorectal cancer. Prior to initiating chemotherapy, diets enriched either with glutamine (2 %, w/w total diet) or n-3 PUFA (0·88 %, w/w total diet) alone, inhibited Ward colon tumour growth (P < 0·05). These diets also completely or partially normalized the changes in peripheral leucocyte counts associated with the tumour-bearing state (e.g. neutrophil proportion/concentration and lymphocyte proportion). During chemotherapy, either glutamine- or n-3 PUFA-enriched diet enhanced tumour chemo-sensitivity, and reduced body weight loss, anorexia and muscle wasting (v. animals fed control diet, P < 0·05). Surprisingly, providing both glutamine and n-3 PUFA together did not confer a greater benefit on tumour inhibition either in the presence or absence of chemotherapy; individual benefits associated with single treatments, particularly in respect to host nutritional status (i.e. body weight, food intake and muscle weight) and immune (peripheral leucocyte counts) features were instead partially or completely lost when these two nutrients were combined. These results draw into question the common assumption that there are additive or synergistic benefits of combinations of nutrients, which are beneficial on an individual basis, and suggest that co-supplementation with glutamine and n-3 PUFA is not indicated during chemotherapy with CPT-11 and 5-FU.
Date created
2009
DOI
doi:10.7939/R3JH3DG3T
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© The Authors 2009
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Citation for previous publication
Xue, H., Le Roy, S., Sawyer, M. B., Field, C. J., Dieleman, L. A., & Baracos, V. E. (2009). Single and combined supplementation of glutamine and n-3 polyunsaturated fatty acids on host tolerance and tumour response to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (CPT-11)/5-fluorouracil chemotherapy in rats bearing Ward colon tumour. British Journal of Nutrition, 102(3), 434-442.  http://dx.doi.org/10.1017/S0007114508199482

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File title: Single and combined supplementation of glutamine and n-3 polyunsaturated fatty acids on host tolerance and tumour response to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (CPT-11)/5-fluorouracil chemotherapy in rats bearing ...
File author: Hongyu Xue, Séverine Le Roy, Michael B. Sawyer, Catherine J. Field, Levinus A. Dieleman, Vickie E. Baracos
File author: Hongyu Xue, Sverine Le Roy, Michael B. Sawyer, Catherine J. Field, Levinus A. Dieleman, Vickie E. Baracos
Page count: 9
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