ERA

Download the full-sized PDF of Aortic Stiffness Across The Heart Failure ContinuumDownload the full-sized PDF

Analytics

Share

Permanent link (DOI): https://doi.org/10.7939/R37W67D7X

Download

Export to: EndNote  |  Zotero  |  Mendeley

Communities

This file is in the following communities:

Graduate Studies and Research, Faculty of

Collections

This file is in the following collections:

Theses and Dissertations

Aortic Stiffness Across The Heart Failure Continuum Open Access

Descriptions

Other title
Subject/Keyword
aortic stiffness
aortic stiffness in heart failure patients
aortic distensibility
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Meena, Neha
Supervisor and department
Dr. Mark Haykowsky (Rehabilitation Medicine)
Examining committee member and department
Dr. Margaret McNelly (Rehabilitation Medicine)
Dr. Richard Thompson (Biomedical Engineering)
Dr. Edith Pituskin (Oncology)
Department
Faculty of Rehabilitation Medicine
Specialization
Rehabilitation Science- Physical Therapy
Date accepted
2014-12-18T10:38:36Z
Graduation date
2015-06
Degree
Master of Science
Degree level
Master's
Abstract
Aim: The purpose of this thesis was to examine aortic stiffness across the heart failure (HF) continuum. Background: Aortic distensibility (AD) decreases with advancing age. In the presence of underlying cardiovascular disease, AD is reduced beyond what which occurs with normal aging. Currently, no study has examined AD in individuals at risk for or with HF. Methods: 149 subjects were assigned into four different groups: healthy controls (n=37, mean±SD, age: 62±10 ys), at risk of developing HF (n=46, age: 62±11 ys), HFpEF (n=32, age: 69±11 ys), and HFrEF (n=34, age: 65±9 ys). Ascending and descending AD and ventricular vascular coupling (AV) were measured using cardiac magnetic resonance imaging (cMRI). Results: Descending AD was significantly lower in the at-risk group compared to HFrEF group. No significant difference was found for ascending AD. In addition, HFrEF individuals had significantly impaired ventricular-arterial coupling compared to all other groups. Conclusion: HFpEF individuals have more marked impairment of arterial compliance, as evidenced by significantly decreased AD compared with controls, with respect to aging. HFrEF individuals had significantly impaired ventricular-arterial coupling, due to impaired systolic function. These findings are clinically important in assessing HF patients and monitoring their arterial stiffness progression. In addition, these findings are important for target therapies that can be beneficial for reversing arterial stiffness in these individuals to improve the outcomes.
Language
English
DOI
doi:10.7939/R37W67D7X
Rights
This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for the purpose of private, scholarly or scientific research. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
Citation for previous publication

File Details

Date Uploaded
Date Modified
2014-12-18T17:38:39.650+00:00
Audit Status
Audits have not yet been run on this file.
Characterization
File format: pdf (PDF/A)
Mime type: application/pdf
File size: 2172911
Last modified: 2016:06:16 16:54:46-06:00
Filename: Meena_Neha_201412_MSC.pdf
Original checksum: 3f868d88e2da2fec471c51f543241494
Activity of users you follow
User Activity Date