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Permanent link (DOI): https://doi.org/10.7939/R3HM52Z7C

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Isoferulic acid, a new anti-glycation agent, inhibits fructose- and glucose-mediated protein glycation in vitro Open Access

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Author or creator
Meeprom, Aramsri
Sompong, Weerachat
Chan, Catherine B.
Adisakwattana, Sirichai
Additional contributors
Subject/Keyword
Protein Oxidation
Isoferulic Acid
Fructosamine
Protein Glycation
Advanced Glycation End Products
Nε-(Carboxymethyl)Lysine
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
The inhibitory activity of isoferulic acid (IFA) on fructose- and glucose-mediated protein glycation and oxidation of bovine serum albumin (BSA) was investigated. Our data showed that IFA (1.25–5 mM) inhibited the formation of fluorescent advanced glycation end products (AGEs) and non-fluorescent AGE [Nε-(carboxymethyl) lysine: CML], as well as the level of fructosamine. IFA also prevented protein oxidation of BSA indicated by decreasing protein carbonyl formation and protein thiol modification. Furthermore, IFA suppressed the formation of β-cross amyloid structures of BSA. Therefore, IFA might be a new promising anti-glycation agent for the prevention of diabetic complications via inhibition of AGEs formation and oxidation-dependent protein damage.
Date created
2013
DOI
doi:10.7939/R3HM52Z7C
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Attribution-NonCommerical-ShareALike 4.0 International
Citation for previous publication
Meeprom, A., Sompong, W., Chan, C. B., & Adisakwattana, S. (2013). Isoferulic acid, a new anti-glycation agent, inhibits fructose- and glucose-mediated protein glycation in vitro. Molecules, 18(6), 6439-6454.  http://dx.doi.org/10.3390/molecules18066439

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File title: Isoferulic Acid, a New Anti-Glycation Agent, Inhibits Fructose- and Glucose-Mediated Protein Glycation in Vitro
File author: Aramsri Meeprom, Weerachat Sompong, Catherine B. Chan, Sirichai Adisakwattana
File author: mdpi
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