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Permanent link (DOI): https://doi.org/10.7939/R3610W56Z

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Neutrophil elastase alters the murine gut mirobiota resulting in enhanced Salmonella colonization Open Access

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Author or creator
Gill, Navkiran
Ferreira, Rosana B. R.
Antunes, L. Caetano M.
Willing, Benjamin P.
Sekirov, Inna
Al-Zahrani, Fatimah
Hartmann, Martin
Finlay, B. Brett
Additional contributors
Subject/Keyword
Gastrointestinal Tract
Streptomycin
Salmonellosis
Inflammation
Neutrophils
Gut Bacteria
Microbiome
Salmonella
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
The intestinal microbiota has been found to play a central role in the colonization of Salmonella enterica serovar Typhimurium in the gastrointestinal tract. In this study, we present a novel process through which Salmonella benefit from inflammatory induced changes in the microbiota in order to facilitate disease. We show that Salmonella infection in mice causes recruitment of neutrophils to the gut lumen, resulting in significant changes in the composition of the intestinal microbiota. This occurs through the production of the enzyme elastase by neutrophils. Administration of recombinant neutrophil elastase to infected animals under conditions that do not elicit neutrophil recruitment caused shifts in microbiota composition that favored Salmonella colonization, while inhibition of neutrophil elastase reduced colonization. This study reveals a new relationship between the microbiota and the host during infection.
Date created
2012
DOI
doi:10.7939/R3610W56Z
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Attribution 4.0 International
Citation for previous publication
Gill, N., Ferreira, R. B. R., Antunes, L. C. M., Willing, B. P., Sekirov, I., Al-Zahrani, F., Hartmann, M., & Finlay, B. B. (2012). Neutrophil elastase alters the murine gut mirobiota resulting in enhanced Salmonella colonization. PLoS ONE, 7(11), e49646 [12 pages].  http://dx.doi.org/10.1371/journal.pone.0049646

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