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Permanent link (DOI): https://doi.org/10.7939/R34F1MS54

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Fabrication and testing of surface-enhanced Raman spectroscopy substrates for the detection of biomolecules Open Access

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Other title
Subject/Keyword
Surface-enhanced Raman spectroscopy
Nanoimprinting
Biosensing
Nanofabrication
Electron Beam Lithography
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
Peters, Robert F
Supervisor and department
Dew, Steven (Electrical and Computer Engineering)
Stepanova, Maria (Electrical and Computer Engineering)
Examining committee member and department
Stepanova, Maria (Electrical and Computer Engineering)
Dew, Steven (Electrical and Computer Engineering)
Jeremy, Sit (Electrical and Computer Engineering)
McCreery, Richard (Chemistry)
Department
Department of Electrical and Computer Engineering
Specialization
Microsystems and Nanodevices
Date accepted
2014-01-07T15:20:26Z
Graduation date
2014-06
Degree
Master of Science
Degree level
Master's
Abstract
Biosensing involves the detection of analytes using biological elements as receptor agents for the specific binding of molecules to a surface. Surface-enhanced Raman spectroscopy (SERS), a surface-sensitive vibrational spectroscopy technique used to amplify Raman signals, provides unique advantages for biosensing. Unique Raman fingerprint spectra of targeted molecules allows for accurate identification of unknown samples. Inconsistencies in Raman signal enhancements, however, due to the irregularities of metallic features at the nanoscale, is a significant challenge with SERS. Nanofabrication technologies, including electron beam lithography (EBL) and nanoimprint lithography (NIL), provide resolution capabilities at the nanoscale. In this work, nanofabrication methods were used to fabricate SERS substrates for the detection of analytes using various immobilization strategies. Control over signal intensity and detection of biological bonding, with analytes in aqueous solutions was demonstrated. Investigations and testing of various aspects in the fabrication processes allowed for significant control over features at nanoscale dimensions.
Language
English
DOI
doi:10.7939/R34F1MS54
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
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