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Permanent link (DOI): https://doi.org/10.7939/R3X31N

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Glutamate Levels in the Medial Prefrontal Cortex of Healthy Women during Pregnancy and the Postpartum Open Access

Descriptions

Other title
Subject/Keyword
Postpartum
Glutamate
Pregnancy
Proton Magnetic Resonance Spectroscopy
Type of item
Thesis
Degree grantor
University of Alberta
Author or creator
McEwen, Alyssa M
Supervisor and department
Dr.Jean-Michel Le Melledo (Psychiatry)
Examining committee member and department
Dr.Esther Fujiwara (Psychiatry)
Dr.Chris Hanstock (Biomedical Engineering)
Dr.Glen Baker (Psychiatry)
Department
Department of Psychiatry
Specialization

Date accepted
2012-08-30T15:04:58Z
Graduation date
2012-11
Degree
Master of Science
Degree level
Master's
Abstract
The substantial female hormone fluctuations associated with pregnancy and the postpartum have been linked to a greater risk of developing depressive symptoms. Glutamate (Glu) has been implicated in the pathophysiology of major depression. The objective of this thesis was to investigate MPFC Glu levels from late pregnancy up to 7 weeks postpartum in women at a high risk for developing depressive symptoms and to compare MPFC Glu levels during late pregnancy in healthy pregnant and non-pregnant women. Using in vivo proton magnetic resonance spectroscopy (1H-MRS) we acquired single-voxel spectra from the MPFC of women. We found fluctuations of MPFC Glu levels from pregnancy up to 7 weeks postpartum in high risk women (HRW) compared to healthy controls (HCs). As well as decreased %GM during pregnancy and the early postpartum in both HRW and HCs with a progressive normalization as the postpartum progressed. Findings may implicate Glu alterations and hormone fluctuations in the pathophysiology of PPD.
Language
English
DOI
doi:10.7939/R3X31N
Rights
Permission is hereby granted to the University of Alberta Libraries to reproduce single copies of this thesis and to lend or sell such copies for private, scholarly or scientific research purposes only. Where the thesis is converted to, or otherwise made available in digital form, the University of Alberta will advise potential users of the thesis of these terms. The author reserves all other publication and other rights in association with the copyright in the thesis and, except as herein before provided, neither the thesis nor any substantial portion thereof may be printed or otherwise reproduced in any material form whatsoever without the author's prior written permission.
Citation for previous publication
McEwen et al., 2012. Neuropsychopharmacology. doi: 10.1038/npp.2012.101. [Epub ahead of print].

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