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Permanent link (DOI): https://doi.org/10.7939/R3QF8JZ40

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Understanding postprandial inflammation and its relationship to lifestyle behaviour and metabolic diseases Open Access

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Author or creator
Klop, Boudewijn
Proctor, Spencer D.
Mamo, John C.
Botham, Kathleen M.
Cabezas, Manuel C.
Additional contributors
Subject/Keyword
Inflammation
Cell Adhesion Molecules
Atherosclerosis
Metabolic Disorders
Lipoproteins
Hyperlipidemia
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Postprandial hyperlipidemia with accumulation of remnant lipoproteins is a common metabolic disturbance associated with atherosclerosis and vascular dysfunction, particularly during chronic disease states such as obesity, the metabolic syndrome and, diabetes. Remnant lipoproteins become attached to the vascular wall, where they can penetrate intact endothelium causing foam cell formation. Postprandial remnant lipoproteins can activate circulating leukocytes, upregulate the expression of endothelial adhesion molecules, facilitate adhesion and migration of inflammatory cells into the subendothelial space, and activate the complement system. Since humans are postprandial most of the day, the continuous generation of remnants after each meal may be one of the triggers for the development of atherosclerosis. Modulation of postprandial lipemia by lifestyle changes and pharmacological interventions could result in a further decrease of cardiovascular mortality and morbidity. This paper will provide an update on current concepts concerning the relationship between postprandial lipemia, inflammation, vascular function, and therapeutic options.
Date created
2012
DOI
doi:10.7939/R3QF8JZ40
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Attribution 4.0 International
Citation for previous publication
Klop, B., Proctor, S. D., Mamo, J. C. L., Botham, K., & Cabezas, M. C. (2012). Understanding postprandial inflammation and its relationship to lifestyle behaviour and metabolic diseases. International Journal of Vascular Medicine, 2012(947417), [11 pages].  http://dx.doi.org/10.1155/2012/947417

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