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Permanent link (DOI): https://doi.org/10.7939/R3NZ8137K

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Increased hypolipidemic benefits of cis-9, trans-11 conjugated linoleic acid in combination with trans-11 vaccenic acid in a rodent model of the metabolic syndrome, the JCR:LA-cp rat Open Access

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Author or creator
Jacome-Sosa, M. Miriam
Lu, Jing
Wang, Ye
Ruth, Megan R.
Wright, David C.
Reaney, Martin J.
Shen, Jianheng
Field, Catherine J.
Vine, Donna F.
Proctor, Spencer D.
Additional contributors
Subject/Keyword
Glucose-Tolerance
Oxidative Stress
Induced Insulin-Resistance
Skeletal-Muscle
Reactive Protein
Healthy-Young Men
Cardiovascular-Disease
Mitochondrial Biogenesis
High-Fat Diet
Adipose-Tissue
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Background Conjugated linoleic acid (cis-9, trans-11 CLA) and trans-11 vaccenic acid (VA) are found naturally in ruminant-derived foods. CLA has been shown to have numerous potential health related effects and has been extensively investigated. More recently, we have shown that VA has lipid-lowering properties associated with reduced hepatic lipidogenesis and chylomicron secretion in the JCR:LA-cp rat. The aim of this study was to evaluate potential additional hypolipidemic effects of purified forms of CLA and VA in an animal model of the metabolic syndrome (the JCR:LA-cp rat). Methods Twenty four obese JCR:LA-cp rats were randomized and assigned to one of three nutritionally adequate iso-caloric diets containing 1% w/w cholesterol and 15% w/w fat for 16 wk: 1) control diet (CD), 2) 1.0% w/w cis-9, trans-11 CLA (CLA), 3) 1.0% w/w VA and 1% w/w cis-9, trans-11 CLA (VA+CLA). Lean rats were fed the CD to represent normolipidemic conditions. Results Fasting plasma triglyceride (TG), total cholesterol and LDL-cholesterol concentrations were reduced in obese rats fed either the CLA diet or the VA+CLA diet as compared to the obese control group (p < 0.05, p < 0.001; p < 0.001, p < 0.01; p < 0.01, p < 0.001, respectively). The VA+CLA diet reduced plasma TG and LDL-cholesterol to the level of the normolipidemic lean rats and further decreased nonesterified fatty acids compared to the CLA diet alone. Interestingly, rats fed the VA+CLA diet had a higher food intake but lower body weight than the CLA fed group (P < 0.05). Liver weight and TG content were lower in rats fed either CLA (p < 0.05) or VA+CLA diets (p < 0.001) compared to obese control, consistent with a decreased relative protein abundance of hepatic acetyl-CoA carboxylase in both treatment groups (P < 0.01). The activity of citrate synthase was increased in liver and adipose tissue of rats fed, CLA and VA+CLA diets (p < 0.001) compared to obese control, suggesting increased mitochondrial fatty acid oxidative capacity. Conclusion We demonstrate that the hypolipidemic effects of chronic cis-9, trans-11 CLA supplementation on circulating dyslipidemia and hepatic steatosis are enhanced by the addition of VA in the JCR:LA-cp rat.
Date created
2010
DOI
doi:10.7939/R3NZ8137K
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Attribution 4.0 International
Citation for previous publication
Jacome-Sosa, M. M., Lu, J., Wang, Y., Ruth, M. R., Wright, D. C., Reaney, M. J., Shen, J., Field, C. J., Vine, D. F., & Proctor, S. D. (2010). Increased hypolipidemic benefits of cis-9, trans-11 conjugated linoleic acid in combination with trans-11 vaccenic acid in a rodent model of the metabolic syndrome, the JCR:LA-cp rat. Nutrition and Metabolism, 7(60), [10 pages].  http://dx.doi.org/10.1186/1743-7075-7-60

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