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Permanent link (DOI): https://doi.org/10.7939/R32805C26

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Trace element supplementation in hemodialysis patients: A randomized controlled trial Open Access

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Author or creator
Tonelli, Marcello
Wiebe, Natasha
Thompson, Stephanie
Kinniburgh, David
Klarenbach, Scott W.
Walsh, Michael
Bello, Aminu K.
Faruque, Labib
Field, Catherine J.
Manns, Braden J.
Hemmalgarn, Brenda R.
Additional contributors
The Alberta Kidney Disease Network
Subject/Keyword
Hemodialysis
Selenium
Zinc
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Background People with kidney failure are often deficient in zinc and selenium, but little is known about the optimal way to correct such deficiency. Methods We did a double-blind randomized trial evaluating the effects of zinc (Zn), selenium (Se) and vitamin E added to the standard oral renal vitamin supplement (B and C vitamins) among hemodialysis patients in Alberta, Canada. We evaluated the effect of two daily doses of the new supplement (medium dose: 50 mg Zn, 75 mcg Se, 250 IU vitamin E; low dose: 25 mg Zn, 50 mcg Se, 250 IU vitamin E) compared to the standard supplement on blood concentrations of Se and Zn at 90 days (primary outcome) and 180 days (secondary outcome) as well as safety outcomes. Results We enrolled 150 participants. The proportion of participants with low zinc status (blood level <815 ug/L) did not differ between the control group and the two intervention groups at 90 days (control 23.9% vs combined intervention groups 23.9%, P > 0.99) or 180 days (18.6% vs 28.2%, P = 0.24). The proportion with low selenium status (blood level <121 ug/L) was similar for controls and the combined intervention groups at 90 days (32.6 vs 19.6%, P = 0.09) and 180 days (34.9% vs 23.5%, P = 0.17). There were no significant differences in the risk of adverse events between the groups. Conclusions Supplementation with low or medium doses of zinc and selenium did not correct low zinc or selenium status in hemodialysis patients. Future studies should consider higher doses of zinc (≥75 mg/d) and selenium (≥100 mcg/d) with the standard supplement.
Date created
2015
DOI
doi:10.7939/R32805C26
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Attribution 4.0 International
Citation for previous publication
Tonelli, M., Wiebe, N., Thompson, S., Kinniburgh, D., Klarenbach, S. W., Walsh, M., Bello, A. K., Faruque, L., Field, C. J., Manns, B. J., & Hemmalgarn, B. R. (2015). Trace element supplementation in hemodialysis patients: A randomized controlled trial. BMC Nephrology, 16(52), [9 pages].  http://dx.doi.org/10.1186/s12882-015-0042-4

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File title: Abstract
File title: Trace element supplementation in hemodialysis patients: a randomized controlled trial
File author: Marcello Tonelli; Natasha Wiebe; Stephanie Thompson; David Kinniburgh; Scott W Klarenbach; Michael Walsh; Aminu K Bello; Labib Faruque; Catherine Field; Braden J Manns; Brenda R Hemmelgarn
Page count: 9
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