ERA

Download the full-sized PDF of Tulane virus recognizes sialic acids as cellular receptorsDownload the full-sized PDF

Analytics

Share

Permanent link (DOI): https://doi.org/10.7939/R34J0B94Q

Download

Export to: EndNote  |  Zotero  |  Mendeley

Communities

This file is in the following communities:

Chemistry, Department of

Collections

This file is in the following collections:

Journal Articles (Chemistry)

Tulane virus recognizes sialic acids as cellular receptors Open Access

Descriptions

Author or creator
Tan, Ming
Xia, Ming
Wei, Chao
Fang, Hao
Quigley, Christina
Huang, Pengwei
Zhong, Weiming
Zhang, Xufu
Fan, Qiang
Klassen, John S.
Jiang, Xi
Additional contributors
Subject/Keyword
Virus-Host Interactions
Molecular Biology
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
The recent discovery that human noroviruses (huNoVs) recognize sialic acids (SAs) in addition to histo-blood group antigens (HBGAs) pointed to a new direction in studying virus-host interactions during calicivirus infection. HuNoVs remain difficult to study due to the lack of an effective cell culture model. In this study, we demonstrated that Tulane virus (TV), a cultivable primate calicivirus, also recognizes SAs in addition to the previously known TV-HBGA interactions. Evidence supporting this discovery includes that TV virions bound synthetic sialoglycoconjugates (SGCs) and that treatment of TV permissive LLC-MK2 cells with either neuraminidases or SA-binding lectins inhibited TV infectivity. In addition, we found that Maackia amurensis leukoagglutinin (MAL), a lectin that recognizes the α-2,3 linked SAs, bound LLC-MK2 cells, as well as TV, by which MAL promoted TV infectivity in cell culture. Our findings further highlight TV as a valuable surrogate for huNoVs, particularly in studying virus-host interactions that may involve two host carbohydrate receptors or co-receptors for infection.
Date created
2015
DOI
doi:10.7939/R34J0B94Q
License information
Attribution 4.0 International
Rights

Citation for previous publication
Tan, M., Xia, M., Wei, C., Fang, H., Quigley, C., Huang, P., Zhong, W., Zhang, X., Fan, Q., Klassen, J., and Jiang, X. (2015). Tulane virus recognizes sialic acids as cellular receptors. Scientific Reports, 5(July), 11784 [14 pages].
Source

Link to related item

File Details

Date Uploaded
Date Modified
Audit Status
Audits have not yet been run on this file.
Characterization
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 1880823
Last modified: 2017:06:24 01:01:45-06:00
Filename: SR_5_July_11784.pdf
Original checksum: 4495ec5f5084fad252af2b4b3878c11b
Copyright note: © 2015 Nature Publishing Group
File title: Tulane virus recognizes sialic acids as cellular receptors
File author: Ming Tan
Page count: 14
Activity of users you follow
User Activity Date