ERA

Download the full-sized PDF of Phytonutrient diet supplementation promotes beneficial Clostridia species and intestinal mucus secretion resulting in protection against enteric infectionDownload the full-sized PDF

Analytics

Share

Permanent link (DOI): https://doi.org/10.7939/R3NZ81382

Download

Export to: EndNote  |  Zotero  |  Mendeley

Communities

This file is in the following communities:

Agricultural, Food and Nutritional Science, Department of

Collections

This file is in the following collections:

Journal Articles (Agricultural, Food and Nutritional Science)

Phytonutrient diet supplementation promotes beneficial Clostridia species and intestinal mucus secretion resulting in protection against enteric infection Open Access

Descriptions

Author or creator
Wlodarska, Marta
Willling, Benjamin P.
Bravo, David M.
Finlay, B.B.
Additional contributors
Subject/Keyword
Escherichia-coli
Mucin
Model
Microbiota
Lactobacillus-sakei
Gene-Expression
Antimicrobial Use
Listeria-monocytogenes
Eugenol
Akkermansia-muciniphila
Type of item
Journal Article (Published)
Language
English
Place
Time
Description
Plant extracts, or phytonutrients, are used in traditional medicine practices as supplements to enhance the immune system and gain resistance to various infectious diseases and are used in animal production as health promoting feed additives. To date, there are no studies that have assessed their mechanism of action and ability to alter mucosal immune responses in the intestine. We characterized the immunomodulatory function of six phytonutrients: anethol, carvacrol, cinnamaldehyde, eugenol, capsicum oleoresin and garlic extract. Mice were treated with each phytonutrient to assess changes to colonic gene expression and mucus production. All six phytonutrients showed variable changes in expression of innate immune genes in the colon. However only eugenol stimulated production of the inner mucus layer, a key mucosal barrier to microbes. The mechanism by which eugenol causes mucus layer thickening likely involves microbial stimulation as analysis of the intestinal microbiota composition showed eugenol treatment led to an increase in abundance of specific families within the Clostridiales order. Further, eugenol treatment confers colonization resistance to the enteric pathogen Citrobacter rodentium. These results suggest that eugenol acts to strengthen the mucosal barrier by increasing the thickness of the inner mucus layer, which protects against invading pathogens and disease.
Date created
2015
DOI
doi:10.7939/R3NZ81382
License information

Rights
Attribution 4.0 International
Citation for previous publication
Wlodarska, Marta, Willling, Benjamin P., Bravo, David M., & Finlay, B.B. (2015). Phytonutrient diet supplementation promotes beneficial Clostridia species and intestinal mucus secretion resulting in protection against enteric infection. Scientific Reports, 5, [9].  https://dx.doi.org/10.1038/srep09253

Source

Link to related item

File Details

Date Uploaded
Date Modified
Audit Status
Audits have not yet been run on this file.
Characterization
File format: pdf (Portable Document Format)
Mime type: application/pdf
File size: 1234005
Last modified: 2017:09:06 16:44:31-06:00
Filename: SR_5_9253.pdf
Original checksum: 02c4bcc48c0c82dd28c9176a525f15b3
Well formed: true
Valid: false
Status message: Invalid destination object offset=1226237
Status message: Invalid destination object offset=1226237
File title: Title
File title: untitled
Page count: 9
Activity of users you follow
User Activity Date